… to repair and re-write genomes, recently developed base-editing systems present a useful
orthogonal strategy to engineer nucleotide substitutions. Base editing relies on recruitment of …

… The availability of protein-only genome editing reagents … the extension of base editing to
the genomes of chloroplasts … base editing methods for nuclear and organellar genomes. We …

… applications of CRISPR-mediated base editing in eukaryotic genomes. … base editors in
rice, which greatly broaden the genome engineering toolkit for plants. The adenine base editors …

… known as base editing, opened new avenues for microbial genome engineering. Base editing
… Here, we review ongoing efforts to develop and apply base editing to engineer industrially …

… -mediated base editing for gene disruption studies. We show that CRISPR base editors
efficiently … Notably, 94%–99% of genes in the analyzed eukaryotic genomes can be targeted with …

… This Review focuses on base editing and prime editing platforms that enable single-…
genomes. We first present a comprehensive overview of the available and forthcoming base editing …

… Base editing is a newer genome-editing approach that uses … DNA base editors comprise
a catalytically disabled nuclease … RNA base editors achieve analogous changes using …

… base editing provides the means for irreversible, permanent changes to the genome, RNA
base editing … Chronologically, RNA base editing predates both DNA base editing and the use …

… for genome editing applications across eukaryotic species, but major drawbacks, such as the
inefficiency of precise base editing … , including base editing, to specific DNA sequences. As …

… this system has been developed into an efficient tool to edit eukaryotic genomes and
revolutionized the field of genome engineering, such as creating complex animal models of human-…