… editing precision and efficiency. We apply G•U wobble base pairs in various RNA base-editing
approaches including the CLUSTER approach, where it greatly improves the guide RNA …

… Furthermore, our sgRNA design also dramatically reduced indels and unwanted base …
sgRNAs of base editors, and our design promises to be adaptable to various base editors. We …

… effectors are usually composed of the DD of an ADAR enzyme, a target-specific guide RNA
(gRNA) and a protein module fused to the DD that tethers the effector protein to the gRNA. …

… base editor that mediates robust editing at various cellular genomic sites together with
moderately modified guide RNA, and … of adenine base editor mRNA and guide RNA expand the …

… in other base editing … base editor options to choose new PAMs and editing windows, we
think implementation of the newest base editors with their experimentally established editing …

… of the software by designing guide RNAs for base editing to model or … base editors and
PAM recognition sequences. To demonstrate the utility of beditor in utilizing custom base editors …

… in editing efficiency. Finally, we show that an adenine base editor 7 can also induce
transcriptome-wide RNA … Guide RNA oligonucleotides used in this study are listed in …

… The continued development of context-dependent base editors 101 or future base editor
variants that lack the ability to bind ssDNA without assistance from the guide RNA represents a …

… DNA base editors. In this Perspective, we discuss the development of DNA base editors, the
guide RNA-… in recent studies, and strategies that improve the selectivity of DNA base editors. …

… system was much efficient than 35S promoter-driven base-editor system. This study provides
guidelines on which a base editor to use and describes how to fine-tune a guide RNA for …