… Base editing induces single-nucleotide changes in the DNA of living cells using a fusion
protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase…

… editing reagents based on transcription activator-like effectors has enabled the extension of
base editing to the … In this review, we summarize currently available base editing methods for …

… of targeted genome editing in living cells. Temporal control over base editing would allow for
… To evaluate if the seBE complex could be used to lie dormant in a cell line until base editing …

… Base editing is a … of living cells. Here, we design an all-in-one episomal vector that expresses
a single guide RNA (sgRNA) with an adenine base editor (ABE) or a cytosine base editor (…

… cells. We also show that base editing can function in vivo in post-mitotic somatic cells that do
not … To improve the targeting scope of base editing, we used our phage-assisted continuous …

… DNA base editing, and discuss the recent progress toward the development of optimized base
editing systems for mammalian cells. … examples of successful base editing in cell lines and …

… editing in animal research studies. Both cytosine and adenine base editors have been applied
successfully to the editing of … Similarly, both base editors have achieved precise editing of …

… base editor constituents, a Cas nuclease variant and a deaminase. In this review, we summarize
information about the DNA base editors … or mitigate those issues of DNA base editors. …

… DNA base editors use deaminases fused to a programmable DNA-binding protein for …
post-translational control in living cells. Here, we present a split adenine base editor (sABE) that …

… We observed highly efficient on-target adenine base edits at these two regulatory regions,
resulting in robust γ-globin induction. Moreover, we developed ABE8e-SpRY, a near-PAMless …