… -based base editors (BEs) are widely used to induce nucleotide substitutions in living cells
and … with the goal of improving adenine base editing efficiency. The reporter system revealed …

… is unquestionably a major breakthrough for the field of mitochondrial genetics because it
allows for the first time purposeful changes to be made in the sequence of mtDNA in living cells. …

… The advent of base editors (BEs) holds great potential for … C-to-T editing is achieved by
BEACON in mammalian cells at … Importantly, BEACON induces in vivo base editing in mouse …

… Although ALS is currently incurable, CRISPR base editors hold … in vivo delivery of cytidine
base editors (CBEs) consisting of the … This work expands the capabilities of single-base editors …

… Base editor purification in a human cell expression system at high purity To produce
recombinant base editor proteins in a human cell system, we cloned the sequences encoding …

… base editors (ABEs) that convert A•T to G•C base pairs in DNA in bacteria and human cells.
… by enabling the direct installation of all four transition mutations at target loci in living cells …

… In an effort to create adenine base editors enabling A-to-G substitutions in organelle DNA,
we first investigated whether fusion proteins containing a TALE protein custom designed to …

… Precise gene editing in human pluripotent stem cells (hPSCs) holds great promise for …
Both prime editing and base editing avoid introducing double strand breaks, but low editing …

… in base editing requires the unwinding of double-stranded DNA (dsDNA)—for example by
a CRISPR–Cas9 system. Base editing … We did not detect indels or base editing outside the …

… Instead of using double-stranded DNA breaks, base editors use nucleobase modification …
) into the genome of living cells. Two classes of DNA base editors currently exist: deoxycytidine …