… To evaluate the off-target effects of base editors at the RNA level, we transfected one type
of CBE (BE3; APOBEC1–nCas9–UGI) or ABE (ABE7.10; TadA–TadA*–nCas9), together with …

… APOBEC1 base editor, consistent with our recent characterization of high editing activity
from CDA- and APOBEC3A-derived CBEs 30 . In contrast, APOBEC3G and AID base editors …

… Although base editors are useful tools for precise genome editing, current base editors
can … We developed a dual adenine and cytosine base editor (A&C-BEmax) by fusing both …

… base editing of endogenous transcripts inside living cells, again with moderate global off-target
effects. The platform should be readily transferable to further epitranscriptomic writers …

… Base editing Base editing is a new technology for the precise modification of genomes (DNA)
or transcriptomes (RNA) of living cells at the single-base resolution. BEs are composed of …

… Base editors present a valuable … base editors (ABEs) produce A·T to G·C changes that can
correct ∼50% of pathogenic point mutations observed in humans, and cytosine base editors (…

… cells with plasmids expressing the base editor and a low-density lipoprotein receptor (LDLR)–targeting
sgRNA. Targeting the base editors … U-to-C edit in the corresponding LDLR mRNA …

… ability to study proteins in living cells and organisms. … base editor screens have been used
to interrogate protein function at amino acid-level resolution, which we refer to as “base editor …

… There are two main DNA base editors developed to date enabling the conversion of all
four DNA base pairs: Cytosine base editors (CBE) and Adenine base editors (ABE) [5]. …

… base into another at a targeted genomic locus. The advanced base editing technique enables
a single-base … -point mutations, CRISPR base editing has advantages in research and in …