… Furthermore, our data suggested that the indels of base editing are … the base editing
mechanism, this work first elucidates the key roles of TLS polymerases in the cytosine base editing …

… base editor, AYBE, for A-to-C and A-to-T transversion editing in mammalian cells by fusing an
adenine base editor (ABE) … targeted editing at genomic loci with higher transversion editing …

… We developed one-time genome editing approaches targeting endogenous SMN2 that …
disease phenotypes in cell and mouse models of SMA. We tested 79 base editing and nuclease …

… patients with sickle cell disease, transduction with the base editor vector mediated efficient
–… phenotypic correction of erythroid cells. Because our in vivo base editing strategy is safe and …

… types of base editing in mice. As a single-component system originated from human proteins,
REWIRE presents a precise and efficient RNA editing platform with broad applicability. …

… Next, we evaluated the efficacy of Cas9-RNP@SN-mediated gene editing in live cells. To
quantitatively measure the knockout of gene expression, we prepared green fluorescent …

… We demonstrate an adenine base editing (ABE) strategy to restore CD3δ in autologous
hematopoietic stem and progenitor cells (HSPCs). Delivery of mRNA encoding a laboratory-…

… -editing enzymes that have been repurposed or redesigned and developed into programmable
base editors… Collectively, base editors derived from these DNA-editing enzymes facilitate …

… However, current base editors can induce unwanted bystander … Here, we develop a new
base editor which significantly … , we compared the editing activities of six base editor fusions at …

… mutation in the cell’s DNA. Here, we demonstrate the implementation of dCas12a base
editors with inducible guides for highly scalable molecular recording in mammalian cells. Our …