… of single base editing by APOBEC-Cas9 editosomes in living cells. These eGFP reporters
enabled us to perform the first comprehensive analysis of base editing capabilities of the entire …

… Genome editing of hematopoietic stem cells allows correction of underlying mutations as …
-break–based editors, base editors (BEs) catalyze base transitions for precision editing of DNA …

… -inducible base editor called the padCas13 editor, which can enable RNA base editing with
… and precisely control endogenous transcripts in living cells to significantly alter the target …

… Although our base editor has a 5 nt editing window, only −17 and −18 positions were
edited with very high efficiencies up to 100%. While positions −16, −19, and −20 could only be …

… Using cytosine base editors we observed premature stop codon introduction in up to 89…
base editors we eliminated the start codon in CCR5 in up to 95% of primary human CD4 + T cell …

… Furthermore, our sgRNA design also dramatically reduced indels and unwanted base …
sgRNAs of base editors, and our design promises to be adaptable to various base editors. We …

… by the Z mutation, a single-base substitution that leads to AAT protein misfolding and … apply
adenine base editors to correct the Z mutation in patient induced pluripotent stem cells (iPSCs…

… Cytosine base editors (CBEs) are gene-editing enzymes capable of programmably
introducing C·G-to-T·A base pair changes in the genomic DNA of living cells. This chemical …

… of base editing remains a daunting challenge. Herein, we develop a photoactivatable base
editor (Mag-ABE) for spatiotemporally controlled genome editing in vivo for the first time. The …

… DNA encoding the adenine base editor (ABE) and a … base editor that displayed higher
base-editing efficiency than the standard ABEs. Our findings suggest that adenine base editing …