Base editing: precision chemistry on the genome and transcriptome of living cells
… editing by-products. In this Review, we summarize base-editing strategies to generate specific
and precise … scope, specificity, precision and in vivo delivery of base editors and discuss …
and precise … scope, specificity, precision and in vivo delivery of base editors and discuss …
Base editing: advances and therapeutic opportunities
EM Porto, AC Komor, IM Slaymaker… - Nature Reviews Drug …, 2020 - nature.com
… -nucleotide alterations in a precise and efficient manner is base editing. Base editing is unique
in … in the process of genome and transcriptome editing (Figs 1 and 2). Both DNA and RNA …
in … in the process of genome and transcriptome editing (Figs 1 and 2). Both DNA and RNA …
Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells.
HA Rees, DR Liu - Nature Reviews. Genetics, 2018 - europepmc.org
The originally published article contained errors in reference numbering throughout table 1 (DNA
base editors and their approximate editing windows) due to the unintended …
base editors and their approximate editing windows) due to the unintended …
Precision RNA base editing with engineered and endogenous effectors
LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
… –Crick base-pairing rules. A great advantage for the basic engineering of A-to-I base editing
is the … A-to-I editing effectors are usually composed of the DD of an ADAR enzyme, a target-…
is the … A-to-I editing effectors are usually composed of the DD of an ADAR enzyme, a target-…
[HTML][HTML] Current status and challenges of DNA base editing tools
… information about the DNA base editors that have been developed … to minimize or mitigate
those issues of DNA base editors. … scope and precision of base editing with engineered Cas9-…
those issues of DNA base editors. … scope and precision of base editing with engineered Cas9-…
Engineering a precise adenine base editor with minimal bystander editing
L Chen, S Zhang, N Xue, M Hong, X Zhang… - Nature Chemical …, 2023 - nature.com
… 1c), suggesting it is possible to innovate pure CBE, C-to-G base editors or dual-base editors
… a base editor with a refined editing window is challenging, especially editing a specific base …
… a base editor with a refined editing window is challenging, especially editing a specific base …
CRISPR/Cas-mediated base editing: technical considerations and practical applications
… Base editing represents a new dimension of CRISPR/Cas-mediated precise editing to
generate single-nucleotide changes in DNA or RNA independently of double-strand breaks and …
generate single-nucleotide changes in DNA or RNA independently of double-strand breaks and …
High-purity production and precise editing of DNA base editing ribonucleoproteins
… base editing tools, which include cytosine base editors (CBEs) and adenine base editors
(ABEs), are capable of inducing precise base … Thus, base editors have been widely used in a …
(ABEs), are capable of inducing precise base … Thus, base editors have been widely used in a …
Controllable genome editing with split-engineered base editors
KN Berríos, NH Evitt, RA DeWeerd, D Ren… - Nature chemical …, 2021 - nature.com
… , offering a generalizable solution for temporally controlling precision genome editing. … , our
goal was to generate a controllable base editing system. We therefore next aimed to leverage …
goal was to generate a controllable base editing system. We therefore next aimed to leverage …
[HTML][HTML] Perturbing proteomes at single residue resolution using base editing
PC Després, AK Dubé, M Seki, N Yachie… - Nature …, 2020 - nature.com
… precise modification of genes, but have yet to be used at a genome-scale throughput. Here,
we test the ability of the Target-AID base editor … context of base editing. Our results show that …
we test the ability of the Target-AID base editor … context of base editing. Our results show that …
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