… Because new base editors significantly reduce unintended editing in the … base editors,
assess their technical advantages and limitations, and discuss their broad applications in basic …

… Practical considerations for design and implementation of base … of DNA base editing, and
discuss the recent progress toward the development of optimized base editing systems for …

… the technical difficulties around gene editing … base edits in the creation of various stem
cell-based models, and the unique characteristics of stem cells that warrant special considerations…

… The first generation of base editors had an editing window of a few base pairs, causing … ,
a high-precision base editor has recently been reported that can selectively edit a single C at a …

… –Crick base-pairing rules. A great advantage for the basic engineering of A-to-I base editing
is the … A-to-I editing effectors are usually composed of the DD of an ADAR enzyme, a target-…

… editing reagents based on transcription activator-like effectors has enabled the extension of
base editing to the … In this review, we summarize currently available base editing methods for …

… Base-editors to create single and multiple nucleotide modifications in cells. Here we
review different base editing … Bases 5–7 of the classical guanine base editor is the CGBE-SpCas9 …

… Cytosine base editors (CBEs) Cytosine base editors are fusions of cytidine deaminases to
… The recent report of a first base editor, the cytosine base editor BE1, [3] was rapidly followed …

… 1, two kinds of base editors have been introduced thus far, which are classified as cytosine
base editors (CBEs) and adenine base editors (ABEs). The impaired Cas9 in CBEs could not …

… We found that ABEs (adenine base editors) had better fidelity than CBEs (cytosine base
editors). Our system could be harnessed as a base editing assessment platform, which would …