… basic sciences from 1980 to the present day (Chapters 3 and 5–8). Section II (Clinical Practice…
shunting, with an emphasis on “disease mechanisms”. Our aim is to provide a concise and …

… mechanisms and their complexity. In this paper, we argue that mechanisms remain central to
clinical practice, and … Mechanistic reasoning enters into clinical decision making at multiple …

… An index episode of ventricular tachycardia is usually followed with several days’
maintenance infusions of antiarrhythmic drugs, which is a common clinical practice. Specialized …

Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

… Since then, basic and clinical researchers in epilepsy have gathered together each decade
to … This new classification, conceived with an emphasis on basic mechanisms, represents …

The hereditary motor and sensory neuropathies (also known as Charcot–Marie–Tooth
disease or CMT) are characterized by a length-dependent loss of axonal integrity in the PNS, …

… of basic research into AF mechanisms to arrhythmia management. Here, we review recent
insights into the basic mechanisms of AF, critically analyse the role of basic … in clinical practice, …

… the key words bisphosphonate and clinical practice in a … mechanisms by which
bisphosphonates exert their effects on osteoclasts, discuss the role of bisphosphonates in clinical …

Endothelium plays an essential role in human homeostasis by regulating arterial blood
pressure, distributing nutrients and hormones as well as providing a smooth surface that …

… Notably the malignant nature of diabetic dyslipidaemia is not completely shown by the lipid
measures used in clinical practice. The key question is what are the mechanisms behind the …