… various biologic responses to insulin remain somewhat elusive… insulin receptor, inheritance
of insulin resistance, insulin receptor and alleles, enzyme activity in insulin resistance, insulin …

… of insulin release, as well as the fasting plasma insulin concentra… in proportion to the severity
of the insulin resistance (r … severity of insulin resistance and adjust its secretion of insulin to …

… Genetic mutations of the insulin gene as the source of insulin resistance have been … of
the insulin receptor gene have been identified as the cause of the extreme insulin resistance, …

… In this review, both the physiology of insulin action and the pathophysiology of insulin
resistance are … of insulin resistance in section IV, we proceed to examine its mechanistic basis. …

… insulin resistance are also covered. Despite our incomplete understanding of the complex
biological mechanisms of insulin action and insulin resistance, … upon this basic predisposition. …

… However, the broad prevalence of insulin resistance and its association with profound … the
pathophysiology of insulin resistance. Before considering the molecular basis for this disorder, …

… cytokines) to produce an insulin-resistant state that often leads … insulin resistance pathways
can help lead to the rational design of novel therapeutic agents for treating insulin resistance …

… The first relates to the genetic basis for syndromes of extreme insulin resistance. The …
function of the insulin receptor have been defined. A genetic basis for insulin resistance in more …

… effective therapies to better treat our patients with insulin resistance and Type 2 diabetes. …
contribute to insulin resistance and Type 2 diabetes. The detailed understanding of these basic …

… insulin receptor (IR) and of its major insulin receptor substrates, IRS-1 and IRS-2. To unravel
the molecular basis for this uncoupling in insulin … IRS-2 with the insulin receptor. We could …