[HTML][HTML] Long non-coding RNA GAS5 promotes BAX expression by competing with microRNA-128-3p in response to 5-fluorouracil

H Lee, H Kang, C Kim, JL Ku, S Nam, EK Lee - Biomedicines, 2022 - mdpi.com
BAX expression by targeting the 3′UTR of BAX mRNA [41], and the miR-128-3p/BAX axis
is … We demonstrate that lncRNA GAS5 enhances BAX expression by interfering with miR-128-…

[HTML][HTML] Long non‑coding RNA GAS5 regulates myocardial ischemia‑reperfusion injury through the PI3K/AKT apoptosis pathway by sponging miR‑532‑5p

Y Han, N Wu, F Xia, S Liu, D Jia - … Journal of Molecular …, 2020 - spandidos-publications.com
… of lncRNA GAS5 in MIRI. The present study reported that the expression of lncRNA GAS5
in … (D) Protein expression of Bax in H9c2 cells detected by western blotting. (E) Quantitative …

Downregulation of lncRNA GAS5 prevents mitochondrial apoptosis and hypoxic-ischemic brain damage in neonatal rats through the microRNA-128-3p/Bax/Akt/GSK …

L Wang, Z Zhang, H Wang - Neuroreport, 2021 - journals.lww.com
… investigated the mechanisms of lncRNA GAS5/miR-128-3p/Bax axis in the … GAS5
prevents mitochondrial apoptosis in neonatal HIBD rats through the ceRNA network of miR-128-3p/Bax

Long noncoding RNA GAS5 acts as a tumor suppressor in laryngeal squamous cell carcinoma via miR-21

K Lyu, Y Xu, H Yue, Y Li, J Zhao, L Chen… - Cancer management …, 2019 - Taylor & Francis
GAS5 and BAX/CDK6. The results indicated that GAS5 was significantly positive correlated
with BAX, while negative correlated with CDK6 expression (Figure S1). Collectively, all these …

[HTML][HTML] Gas5 exerts tumor-suppressive functions in human glioma cells by targeting miR-222

X Zhao, P Wang, J Liu, J Zheng, Y Liu, J Chen, Y Xue - Molecular Therapy, 2015 - cell.com
… of Gas5 in glioma, we first investigated Gas5 expression levels … As shown in Figure 1a, Gas5
expression was much lower in … expression of proapoptotic protein bmf, which elevated Bax

[HTML][HTML] Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in …

T Le, X He, J Huang, S Liu, Y Bai, K Wu - Journal of Translational …, 2021 - Springer
… Furthermore, Western blot analysis showed that GAS5 silencing led to decreased cleaved
caspase-3 and Bax expression and increased Bcl-2 expression as compared with the NCs, …

Long non-coding RNA GAS5 regulates the growth and metastasis of human cervical cancer cells via induction of apoptosis and cell cycle arrest

Z Yan, L Ruoyu, L Xing, L Hua, Z Jun, P Yaqin… - Archives of biochemistry …, 2020 - Elsevier
… of Bax and Bcl-2 apoptosis related proteins confirmed that Bax protein level … GAS5 long
no-coding RNA in cervical cancer. Results indicate the molecular therapeutic potential of GAS5

[HTML][HTML] LncRNA GAS5 regulates vascular smooth muscle cell cycle arrest and apoptosis via p53 pathway

R Tang, X Mei, YC Wang, XB Cui, G Zhang, W Li… - … et Biophysica Acta (BBA …, 2019 - Elsevier
… of GAS5 on p53 signaling pathway, p53 downstream genes BAX, PUMA, NOXA and p21
mRNA expression … 3E, overexpression of GAS5 increased the mRNA expression of all the p53 …

[HTML][HTML] Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway

J Gao, M Liu, Y Zou, M Mao, T Shen… - Oncology …, 2015 - spandidos-publications.com
… study revealed that GAS5 is downregulated in EOC specimens, and GAS5 inhibits EOC cell
… (A) Expression of BAK and BAX are shown by western blotting. The cells were treated with …

[HTML][HTML] Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription

M Wang, C Guo, L Wang, G Luo, C Huang, Y Li… - Cell death & …, 2018 - nature.com
… In this study, we showed that GAS5 expression level was negatively related to … GAS5 (GAS5-001)
acts as a tumor-suppressive GAS5 transcript, and GAS5-007 is an oncogenic GAS5