… Bcr-Abl inhibitors paved the way of targeted therapy epoch. Imatinib was the first tyrosine
kinase inhibitor to be discovered with high specificity for Bcr-Abl … Bcr-Abl-dependent and Bcr-Abl…

… These more potent BCR-ABL inhibitors may have a more profound effect … Combinations of
BCR-ABL inhibitors, used either … There has been speculation that inhibition of normal tyrosine …

… inhibitors are active against many of the mutations in the Abl kinase that confer resistance to
imatinib. However, resistance remains a major problem, and new inhibitors … of Abl inhibition …

… negligible activity against the frequent BCR–ABL T315I mutation and modest … the ABL
kinase–imatinib complex have resulted in the synthesis of a new generation of BCR–ABL inhibitors…

… investigated the possibility of inhibiting BCR-ABL activity in a more … Several highly potent
next-generation BCR-ABL inhibitors … BCR-ABL and Src inhibitor, and potent selective BCR-ABL …

… has prompted the search for novel Bcr-Abl inhibitors. … The body of the article deals with
Bcr-Abl inhibitors patented since … Overall, Bcr-Abl inhibitors constitute a very appealing research …

… the discovery of new Bcr-Abl inhibitors based on allosteric control. … of the discovery of new
Bcr-Abl allosteric inhibitors. Next, we … of potential Bcr-Abl allosteric inhibitors whose structures, …

… BCR-ABL inhibitors in clinical trials include ABL inhibitors (nilotinib), dual Src family and ABL
kinase inhibitors (… -ATP competitive inhibitors of BCR-ABL (ON012380) and Aurora kinase …

… To uncover new inhibitors of cellular Bcr-abl kinase, we performed a differential
cytotoxicity … new class of Bcr-abl inhibitors that possess excellent selectivity toward Bcr-abl–transformed …

… act as dual inhibitors, targeting not only Bcr-Abl but also other … by the non-ATP-competitive
inhibitors, which may bind to the … Bcr-Abl ATP-competitive and non-ATP-competitive inhibitors …