… a policy of frequent accurate molecular monitoring. Primary refractoriness and acquired …
need for ongoing molecular monitoring even in the best responders. Other ABL kinase inhibitors …

… Importantly, molecular monitoring using BCR–ABL real-time quantitative reverse transcription
… emphasis on the role, application and future aspects of PCR-based molecular monitoring. …

… BCR-ABL mRNA in the blood of patients with CML has become the predominant molecular
monitoring … been used to serially monitor response to IFN and allograft.1, 21, 26, 27 The BCR-…

… Figure 3 describes the results of molecular monitoring in the 6 patients who relapsed. All
these patients had detectable BCR-ABL transcripts before relapse. One-half of them (UPN 273, …

… The aim of this study was to standardize RT-PCR in monitoring BCR-ABL levels in CML
patients treated with tyrosine kinase inhibitors and correlate BCR-ABL levels with cytogenetic …

… of molecular response (MR) levels. Here, we will review the evolution of molecular response
… optimal patient management, how molecular monitoring can best be performed nowadays …

… , thus, mimicked a routine CML monitoring scenario, for which the BCR-ABL1 quantitation is
… control gene for the molecular monitoring of CML. GUSB displayed similar BCR-ABL1 fold …

… molecular response (MR) – had to be defined (Hughes & Branford, 2003). It was soon realized
that only routine molecular monitoring … a 3-log reduction in BCR-ABL1 transcript levels (…

… an MMR (BCR-ABL1/control gene ratio ≤0.1% on the IS), resistance and progression are
unlikely [Citation10]. This is possible through molecular monitoring for BCR-ABL1 mRNA from …

… Molecular monitoring of BCR-ABL1 transcripts for patients … adopted the molecular technique
for measuring BCR-ABL1 and … Overall, molecular monitoring, including low-level monitoring …