Peripheral blood is a source of BCR-ABL-negative pre-progenitors in early chronic phase chronic myeloid leukemia

ID Lewis, DN Haylock, S Moore, LB To, TP Hughes - Leukemia, 1997 - nature.com
blood at diagnosis. Apheresis product collected at diagnosis is a more abundant source
of BCRABL-… Thus, apheresis product could potentially be utilized as a source of BCR-ABL-nega- …

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

SK Chai, GL Nichols, P Rothman - Journal of immunology …, 1997 - journals.aai.org
… find constitutive STAT activation in BCRAbl-expressing cell lines… peripheral blood cells of
patients with BCR-Abl-expressing leukemias. These studies suggest that the expression of BCR

Proliferating status of peripheral blood progenitor cells from patients with BCR/ABL-positive chronic myelogenous leukemia

A Krämer, H Löffler, J Bergmann, A Hochhaus… - Leukemia, 2001 - nature.com
… To investigate the mechanisms behind the leukemic expansion of BCR/ABL-positive …
from peripheral blood (PB) and bone marrow (BM) of 37 patients with newly diagnosed BCR/ABL-…

Serial measurement of BCR-ABL transcripts in the peripheral blood after allogeneic stem cell transplantation for chronic myeloid leukemia: an attempt to define …

J Kaeda, D O'shea, RM Szydlo, E Olavarria, F Dazzi… - Blood, 2006 - ashpublications.org
… persisting low levels of BCR-ABL transcripts but never … BCR-ABL transcript levels after
allograft is variable; only a minority of patients with fluctuating or persistent low levels of BCR-ABL

Serial monitoring of BCRABL by peripheral blood real‐time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic …

L Wang, K Pearson, L Pillitteri… - British journal of …, 2002 - Wiley Online Library
BCRABL expression is relatively high, although having little effect on the ratio obtained from
samples with low BCRABL … that the serial peripheral blood BCRABL/ABL ratio may be …

BCR-ABL protein expression in peripheral blood cells of chronic myelogenous leukemia patients undergoing therapy

JQ Guo, JY Lian, YM Xian, MS Lee, AB Deisseroth… - 1994 - ashpublications.org
ABL band. Our results show that we can detect the BCR-ABL protein both in peripheral blood
… Also, our Western blot assay not only detected P210 BCR-ABL in Ph'-positive CML patients…

STI571: targeting BCR-ABL as therapy for CML

MJ Mauro, BJ Druker - The oncologist, 2001 - academic.oup.com
… trial, 91% of patients showed a hematological response; 63% of patients achieved a
complete hematological response but not all patients had recovery of peripheral blood counts. …

An international study to standardize the detection and quantitation of BCR-ABL transcripts from stabilized peripheral blood preparations by quantitative RT-PCR

MC Müller, G Saglio, F Lin, H Pfeifer, RD Press… - …, 2007 - haematologica.org
BCR-ABL, total ABL, and G6PD transcript concentrations and to calculate the BCR-ABL/total
ABL and BCR-ABL/… calculated using TaqMan PCR for BCR-ABL, total ABL, and G6PD of …

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BcrAbl positive cells

BJ Druker, S Tamura, E Buchdunger, S Ohno… - Nature medicine, 1996 - nature.com
… Cellular proliferation and tumor formation by Bcr-Abl-expressing cells … peripheral blood
or bone marrow from patients with CML, there was a 92–98% decrease in the number of bcr-abl

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

MA Kelliher, J McLaughlin, ON Witte… - Proceedings of the …, 1990 - National Acad Sciences
… of BCR/ABL was present in the peripheral blood samples. … , unique fragment for each
BCR/ABL provirus revealed the … in the peripheral blood is a consequence of BCR/ABL infection …