Synthesis, in vitro α-amylase activity, and molecular docking study of new benzimidazole derivatives

…, F Rahim, I Uddin, M Sarfraz, SAA Shah, A Aziz… - Russian Journal of …, 2021 - Springer
… We have already reported benzimidazole derivatives as α-amylase inhibitors [38] and …
benzimidazole moiety, herein we report a library of new benzimidazole derivatives with α-amylase

Design of novel benzimidazole derivatives as potential α-amylase inhibitors using QSAR, pharmacokinetics, molecular docking, and molecular dynamics simulation …

O Abchir, O Daoui, S Belaidi, M Ouassaf… - Journal of Molecular …, 2022 - Springer
… of benzimidazole derivatives highly affect the bioactivity of these compounds against α-amylase. …
for improving pIC50 of benzimidazole derivatives, fourteen new molecules bearing …

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes

S Hussain, M Taha, F Rahim, S Hayat, K Zaman… - Journal of Molecular …, 2021 - Elsevier
… , benzimidazole and its analogs received much attention by the researchers [4]. Benzimidazole
derivatives … Moreover, many other benzimidazole derivatives were synthesized from 2-…

Synthesis of hydrazine containing piperazine or benzimidazole derivatives and their potential as α-amylase inhibitors by molecular docking, inhibition kinetics and in …

…, E Ayazoglu-Demir, I Demir, A Colak… - Medicinal Chemistry …, 2021 - Springer
… of newly synthesized ligands in α-amylase and calculating their … benzimidazole derivatives.
Designed compounds were synthesized, characterized and screened for in vitro α-amylase

Design of novel benzimidazole derivatives as potential α-amylase inhibitors by 3D-QSAR modeling and molecular docking studies

…, I Aanouz, R El-Mernissi, A Khaldan… - … Society Section A …, 2020 - dergipark.org.tr
… (17) on a series of benzimidazole derivatives against α-amylase in order to develop a
correlation … This would eventually facilitate the design and optimization of new potential α-amylase

[HTML][HTML] … , molecular docking, and bioactivity study of novel hybrid benzimidazole urea derivatives: a promising α-amylase and α-glucosidase inhibitor candidate with …

LM Aroua, AH Alosaimi, FM Alminderej, S Messaoudi… - Pharmaceutics, 2023 - mdpi.com
… as potent α-glucosidase and α-amylase inhibitors. A multitude of benzimidazole derivatives
were reviewed as α-amylase inhibitors including benzimidazole bearing sulfonamide [34], 2-…

2-Aryl benzimidazoles: synthesis, in vitro α-amylase inhibitory activity, and molecular docking study

…, S Chigurupati, I Fatima, M Taha, A Wadood… - European journal of …, 2018 - Elsevier
… We have reported the 5-bromo-2-aryl benzimidazole derivatives as potent inhibitors for α-glucosidase
enzyme [12]. Few benzimidazole chalcone derivatives are reported as α-amylase

A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity

LM Aroua, HR Almuhaylan, FM Alminderej… - Bioorganic …, 2021 - Elsevier
… Most targeted benzimidazole derivatives have an important α-amylase and α-glucosidase …
Most of the elaborated benzimidazole derivatives were found to have inhibitory activity close …

Design, synthesis, and in silico studies of benzimidazole bearing phenoxyacetamide derivatives as α-glucosidase and α-amylase inhibitors

N Shayegan, A Iraji, N Bakhshi, A Moazzam… - Journal of Molecular …, 2022 - Elsevier
… synthesis of benzimidazole derivatives (Compound A… α-glucosidase binding site, this work
focused on the design and synthesis of benzimidazole bearing phenoxyacetamide derivatives

Synthesis, in vitro α-amylase, α-glucosidase activities and molecular docking study of new benzimidazole bearing thiazolidinone derivatives

S Khan, H Ullah, F Rahim, M Nawaz, R Hussain… - Journal of Molecular …, 2022 - Elsevier
… of benzimidazole and thiazolidinone, here in this study we have plan to synthesize
benzimidazole bearing thiazolidinone as a potent alpha-glucosidase and alpha-amylase inhibitors. …