… of low molecular weight protein tyrosine kinase inhibitors which we named tyrphostins. The
… benzylidenemalononitrile moiety. In this article we describe three novel groups of tyrphostins: …

… that the pharmacophores of tyrphostins active against EGF receptor tyrosine kinase are …
group of the benzylidenemalononitriles (BMNs). Preparation of dimeric tyrphostins can be …

… tyrosine kinase as compared to that of EGFR tyrosine kinase. We therefore used compound
6 as our parent compound and studied the effect on the inhibitory activity and selectivity of (a…

… The compoundsdescribed in this publication are derived from benzylidenemalononitrile (BMN)
nucleus. These compounds resemble the moieties tyrosine and erbstatin at the same time…

… A large number of tyrosine kinase inhibitors has been obtained from both natural sources …
tyrphostins'. The common structural feature of most tyrphostins is the benzylidene malononitrile …

… tyrphostins are more selective than genistein, lavendustin A and herbimycin A, each group
inhibits several tyrosine kinases … this reason that tyrosine kinase inhibitors, and tyrphostins in …

… protein tyrosine kinase synthetic inhibitors. The initial benzylidenemalononitrile tyrphostins
… of the other protein tyrosine kinase inhibitors, these tyrphostins are tyrosine mimetics that …

… of small molecules capable to inhibit tyrosine kinases (TYKs), named tyrphostins. They are
… First investigations on benzylidenemalononitrile derivatives started two decades ago, when …

… Tyrphostins include three structurally diverse classes of compounds: the dihydroxy-cis-benzylidene-malononitrile …
of a tyrphostin dihydroxy-cis-benzylidene-malononitrile is very similar …

… a receptor tyrosine kinase (RTK) … tyrosine are known as the tyrphostins. In this project, an
extensive array of 3-arylpropenonitriles (approximately 140 compounds) akin to the tyrphostins …