… Johnson KH, O'Brien TD, Hayden DW, Jordan K, Ghobrial HK, Mahoney WC, Westermark
P: Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of …

… cell in the development and progression of diabetes mellitus. We review advances in our
understanding of the α-cell … the α-cell might become a more prominent target for the treatment of …

… of a molecular genetic classification of monogenic beta-cell diabetes. … beta-cell K(ATP)
channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and …

… of primary beta cells and to include the principles of the 3Rs into the field of diabetes mellitus
… , derivation of cells from transgenic mice or even non-islet cells to produce immortalised …

… -1 PDX-1)] results in a clonal cell line which shows glucose-sensitive insulin … cells, either
pluripotent or committed to be beta cells, represent a potentially unlimited source of beta cells…

… Diabetes mellitus is a multifactorial metabolic disorder characterized by hyperglycemia.
Apoptosis in beta cells … in the β cells in the extrinsic pathway of apoptosis. Cytokines produced in …

… There is a minute-to-minute regulation of insulin output from the Beta cell to meet changing
… insulin production by changes in total Betacell mass. Diabetes mellitus develops if any one of …

… We propose that a central component of therapies for diabetes mellitus should be the
restoration of the missing and/or dysfunctional pancreatic β-cells, the underlying cause of both …

… The treatment of diabetes mellitus represents one of the greatest medical challenges of our
era. Diabetes results from a deficiency or functional impairment of insulin-producing β cells, …

… β-cell mass are crucial in the development of diabetes mellitus. Maturity-onset diabetes of
the young comprises a number of single-gene disorders affecting pancreatic β-cell function, …