… of dosing guidelines that recommend concentration monitoring. Like aminoglycosides,
vancomycin TDM has slowly transitioned from a focus on prevention of vancomycin-induced …

… Pending the result of therapeutic drug monitoring (TDM), we suggest that a higher daily
dose of beta-lactam antibiotics than that administered in patients outside the ICU should be …

… guidelines support the use of prolonged-infusion β-lactams … the infusion of β-lactam antibiotics
and provides guidance for … of the dosing strategy for currently available β-lactams is but …

… Our results align with the literature, where increasing eGFR values were associated with
sub-optimal PK-PD exposures for beta-lactam antibiotics. In our beta-lactam dosing guideline, …

… adherence to an agreed protocol for sampling and dose modification. This service can be
successful and long lasting, as evidenced by the existing β-lactam TDM programmes in place …

… The duration of infusion of beta-lactams has been shown to influence the fT > … beta-lactam
pharmacodynamics profile may be obtained by longer exposure with more frequent dosing, …

… antibiotic dosing and the consequences of therapeutic failure, clinicians have little data to
guide … Accordingly, the available dosing guidelines often are based on PK data obtained from …

… dose optimization strategies to maximize clinical outcomes. The particular emphasis of this
paper will be on beta-lactam … optimal dosing and guide dosing in highly challenging patients. …

… dose regimens. The objective of the present study was to describe current practice for
beta-lactam dosing … Institutional guidelines on beta-lactam dosing during CRRT were rare. 41% of …

… dosing guidelines is affecting antibiotic efficacy and safety in children, and if so whether certain
dosing guidelines … appropriateness in pediatric beta-lactam dosing recommendations for …