Semi-quantitative profiling of bile acids in serum and liver reveals the dosage-related effects of dexamethasone on bile acid metabolism in mice
X Wang, F Wang, Z Lu, X Jin, Y Zhang - Journal of Chromatography B, 2018 - Elsevier
… ), play an important role in regulating the homeostasis of bile acids (BAs). In previous studies,
two-week treatment of 1 mg/kg of dexamethasone (DEX) was used to activate GR in mice, …
two-week treatment of 1 mg/kg of dexamethasone (DEX) was used to activate GR in mice, …
Addition of dexamethasone alters the bile acid composition by inducing CYP8B1 in primary cultures of human hepatocytes
… dexamethasone is a common additive to culture media, we have previously investigated
their effect on bile acid transporters in primary hepatocytes and shown that dexamethasone …
their effect on bile acid transporters in primary hepatocytes and shown that dexamethasone …
Effect of dexamethasone on biliary excretion of bile acids and organic anions in rats
C Suzuki, N Sano, H Takikawa - Hepatology research, 2003 - Elsevier
… have increased the bile acid-independent canalicular bile flow in dexamethasone-treated
rats to some extent, although basal bile flow was unchanged by dexamethasone in the present …
rats to some extent, although basal bile flow was unchanged by dexamethasone in the present …
Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without …
Y Liu, R Havinga, FR Van Der Leij, R Boverhof… - Pediatric …, 2008 - nature.com
… This study addresses effects of early postnatal exposure to GC on hepatic … in bile acid
metabolism and bile acid kinetics in adult rats. Male rats were treated with either dexamethasone (…
metabolism and bile acid kinetics in adult rats. Male rats were treated with either dexamethasone (…
[HTML][HTML] The effects, underlying mechanism and interactions of dexamethasone exposure during pregnancy on maternal bile acid metabolism
M Fang, Q Zhang, P Yu, C Ge, J Guo, Y Zhang… - Toxicology Letters, 2020 - Elsevier
… conservation of bile acid homeostasis under pregnancy or dexamethasone exposure was
… However, dexamethasone exposure during pregnancy tipped the balance of liver bile acid …
… However, dexamethasone exposure during pregnancy tipped the balance of liver bile acid …
Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase
HM Princen, P Meijer, B Hofstee - Biochemical Journal, 1989 - portlandpress.com
… Recently, Everson demonstrated that dexamethasone stimulated bile acid synthesis and
cholesterol 7a-hydroxylase activity in hybrid cells, created by fusing rat hepatocytes with …
cholesterol 7a-hydroxylase activity in hybrid cells, created by fusing rat hepatocytes with …
Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters
W Huang, J Zhou, J Guo, W Hu, G Chen, B Li, Y Wen… - BMC medicine, 2021 - Springer
… Our recent studies found that prenatal dexamethasone exposure … on bile acid (BA) metabolism
in the offspring. The purpose of this study was to investigate the effects of dexamethasone …
in the offspring. The purpose of this study was to investigate the effects of dexamethasone …
FXR-dependent and-independent interaction of glucocorticoids with the regulatory pathways involved in the control of bile acid handling by the liver
… of dexamethasone, prednisolone and budesonide to affect the liver handling of bile acids
(BAs) has been investigated. In rats treated with GCs for 4 days, altered serum and bile BA …
(BAs) has been investigated. In rats treated with GCs for 4 days, altered serum and bile BA …
Glucocorticoid treatment alters systemic bile acid homeostasis by regulating the biosynthesis and transport of bile salts
Y Xiao, W Yan, K Zhou, Y Cao, W Cai - Digestive and Liver Disease, 2016 - Elsevier
… We show here that GRs, in the presence of dexamethasone, repressed the human CYP7A1
gene through two GR-binding sites located on the promoter of CYP7A1 in Huh-7 cells (Fig. 5)…
gene through two GR-binding sites located on the promoter of CYP7A1 in Huh-7 cells (Fig. 5)…
Effects of chronic dexamethasone exposure on bile acid metabolism and cecal epithelia function in goats
C Hua, Y Geng, Q Chen, L Niu, L Cai, S Tao… - Domestic animal …, 2018 - Elsevier
… Bile acids are synthesized via the oxidation of cholesterol in hepatocytes, and BA synthesis
is the major pathway for hepatic cholesterol catabolism. Bile acids … Bile acid in the gut lumen …
is the major pathway for hepatic cholesterol catabolism. Bile acids … Bile acid in the gut lumen …
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