Identification of HSP90 as potential biomarker of biliary atresia using two-dimensional electrophoresis and mass spectrometry

R Dong, P Deng, Y Huang, C Shen, P Xue, S Zheng - PloS one, 2013 - journals.plos.org
… Current diagnosis depends on surgical exploration of the biliary tree. The aim of the
present study was to identify potential biomarkers for the diagnosis of biliary atresia (BA). Two-…

Serum Heat Shock Protein 90 in Diagnosis of Biliary Atresia

MS Eldfrawy, HA Elaraby, SA Elgendy… - Benha Journal of …, 2020 - journals.ekb.eg
… Experimentally, [11] furnished proof that aortic nitric oxide (NO) overproduction done rats
for biliary atresia What's more portal vein stenosis is identified with raised levels for HSP90. …

Exome sequencing in individuals with isolated biliary atresia

R Rajagopalan, EA Tsai, CM Grochowski, SM Kelly… - Scientific reports, 2020 - nature.com
… REV1 is known to be a key player in DNA repair pathway and to interact with HSP90. In …
used to identify genomic changes in a cohort of patients with isolated biliary atresia, and in …

Biliatresone: progress in biliary atresia study

JJ Zhu, YF Yang, R Dong, S Zheng - World Journal of Pediatrics, 2023 - Springer
… “biliary atresia”, “biliatresone”, “GSH”, and “HSP90”. … identification of gene errors linked to
BA remains elusive. A genome-wide association study carried out in a large cohort identified

Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia

X Zhao, K Lorent, D Escobar-Zarate, R Rajagopalan… - Gastroenterology, 2020 - Elsevier
… BA and identified phosphodiesterase 5 inhibitor as a potential treatment for biliary atresia, …
We found that inhibition of Hsp90 sensitized EHCs to low-dose biliatresone (Figure 3B, B′, …

Recent studies on non-invasive biomarkers useful in biliary atresia–a literature review

A Lew-Tusk, M Pęksa… - Acta Biochimica …, 2023 - abp.ptbioch.edu.pl
… To confirm those results, mass spectrometric identification and immunoblotting analysis
of HSP90 were used. Dong and others (Dong et al., ????) suggest that HSP 90 could play a …

Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis

YW Chung-Davidson, CY Yeh, U Bussy, K Li… - BMC developmental …, 2015 - Springer
Hsp90 was identified as a candidate key factor during liver metamorphosis because of its …
process of biliary atresia was completed, the metabolism in hepatocytes resumed. Hsp90 was …

[PDF][PDF] Biliary atresia: clinical and research challenges for the twenty‐first century

JA Bezerra, RG Wells, CL Mack, SJ Karpen… - …, 2018 - Wiley Online Library
… , and whole-exome sequencing of 30 family trios identifying a loss-of-function mutation in
STIP1, encoding a stress-induced HSP90 cochaperone protein, in one child with BA. Zebrafish …

[HTML][HTML] Genetic aspects of biliary atresia etiology

MK Isaeva, AV Degtyareva, VA Belova… - Bulletin of Russian …, 2020 - cyberleninka.ru
… in stress responses have been identified. However, the long-… makes it difficult to identify the
genetic markers. Keywords: … with the heat-shock protein HSP90 and are involved in stress-…

Serum microRNA microarray analysis identifies miR-4429 and miR-4689 are potential diagnostic biomarkers for biliary atresia

R Dong, Z Shen, C Zheng, G Chen, S Zheng - Scientific Reports, 2016 - nature.com
… In this study, 13 differentially expressed miRNAs were identified using the Agilent miRNA …
III InsP3R in the cholangiocytes of patients with biliary atresia is associated with impaired Ca2+ …