Effect of genipin on the biliary excretion of cholephilic compounds in rats

M Mikami, H Takikawa - Hepatology Research, 2008 - Wiley Online Library
… choleresis by increasing the biliary excretion of glutathione, which … effect of colchicine on
the choleretic effect of genipin was investigated. The effect of genipin on the biliary excretion

[PDF][PDF] Genipin enhances Mrp2 (Abcc2)‐mediated bile formation and organic anion transport in rat liver

J Shoda, T Miura, H Utsunomiya, K Oda… - …, 2004 - Wiley Online Library
… It also increased biliary secretiongenipininduced choleretic activity is mediated by its effect
on Mrp2, the transporter that plays the major role in generation of bile acid-independent bile

Effect of genipin on cholestasis induced by estradiol‐17β‐glucuronide and lithocholate‐3‐O‐glucuornide in rats

H Goto, H Takikawa - Hepatology Research, 2010 - Wiley Online Library
… at the level of biliary LCG excretion. In the present study, we examined the effect of genipin
on … Furthermore, the effect of genipin on the biliary excretion of substrates of P-gp, vinblastine (…

Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats

L Guan, L Zhang, D Gong, P Li, S Zhu… - Journal of Pharmacy …, 2024 - academic.oup.com
… role in bile transportation and … genipin and the role of BAs signals in metabolic regulation,
the present study investigated the effect of genipin on obesity through regulating bile secretion

Effect of penicillin G on the biliary excretion of cholephilic compounds in rats

M Fukami, A Tanka, H Takikawa - Journal of hepato-biliary-pancreatic …, 2011 - Springer
… that genipin increased bile flow and biliary glutathione excretion … reported that genipin inhibited
biliary EM excretion and … ]; however, PCG had no effect on biliary EM excretion and E17G …

Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe

X Fan, L Lin, B Cui, T Zhao, L Mao, Y Song… - Pharmacological …, 2020 - Elsevier
… the biliary tree being coupled with Na + and passive excretiongenipin enhances the
distribution of Mrp2 protein to the bile … rats, genipin ameliorates cholestasis in intrahepatic bile

Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice

M Yamamoto, N Miura, N Ohtake, S Amagaya, A Ishige… - Gastroenterology, 2000 - Elsevier
… the effects of genipin administration on ΔΨ m at 30 and 45 minutes after Jo2 injection. In
normal (Jo2-untreated) mice, genipin administration had no effect on ΔΨ m . In genipin-…

Pharmacological studies of gardenia fruit. V. Mechanisms of inhibitory effect of genipin on gastric acid secretion and its facilitatory effect on bile secretion in rats

M ABURADA, S TAKEDA, M SAKURAI… - Journal of Pharmacobio …, 1980 - jstage.jst.go.jp
biliary bile … , genipin did not affect the biliary bile acid excretion rate at every 15-min period.
DHC showed an increase in the bile acid concentration and bile acid excretion rate in the bile

Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism

Y Zhao, H Huang, N Lv, C Huang, H Chen… - Journal of Agricultural …, 2023 - ACS Publications
… Time-dependent curves of M532-1 formation ((A) relative concentration and (B) cumulative
biliary excretion) in rat bile samples after oral administration of 50 mg/kg GP. EA group rats …

Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers

K Okada, J Shoda, M Kano, S Suzuki… - American Journal …, 2007 - journals.physiology.org
… Administration of ICKT or genipin to rats for 7 days increased bile flow and biliary excretion
of … For bile acid, the rate of biliary excretion of bile acids was significantly increased in …