… We created a database of 103 high-resolution peptide-protein complexes, named peptiDB
(… the binding strategies of short peptides (5 to 15 residues long; Figure 1A) to proteins. The …

… free structures of peptide binding proteins revealed minimal conformational changes induced
in the receptor upon binding to a peptide, thus minimizing the entropic cost of binding [14 •• …

… Deciphering and characterizing peptide–protein recognition mechanisms is … of peptide-based
strategies to interfere with endogenous protein interactions, or improvement of the binding …

… The focus of this review is to introduce current strategies for binding protein surfaces with
emphasis on the use of designed molecules. The progress made to this point has in large part …

… observation that protein functional sites, including peptide binding sites, also bind small organic
… to ligand binding site identification24 and druggable protein–protein interaction sites,25 …

… strategies that were applied for the structure-based design of PPI inhibitors using peptide
binding … For this reason, scaffolds derived from screenings of small-molecule or peptide …

… binding sites of proteins represents a promising strategy for the exploration and understanding
of protein … The ultimate goal of using such molecules is the modulation of protein function …

… on using peptides to study protein–protein interactions in … peptide arrays to identify the
binding regions in both proteins … spot represents binding of the protein to a specific peptide (E)…

… Microarrays of proteins and peptides make it possible the screening of thousands of binding
events in a parallel and high throughput fashion; therefore they are emerging as a powerful …

… It could be argued that a synthetic mimetic of a discontinuous protein binding site should
present the protein-derived peptide fragments also in a sequentially discontinuous and …