The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

T Hodgkinson, PM Tsimbouri, V Llopis-Hernandez… - Science …, 2021 - science.org
… We note that bioactive metabolites might also lend themselves to chemical modification to …
skeletal stem cells—a clonogenic population of nonhematopoietic bone marrow stromal cells

[HTML][HTML] Bioactive lipids in cancer stem cells

RR Begicevic, F Arfuso, M Falasca - World Journal of Stem Cells, 2019 - ncbi.nlm.nih.gov
… This review highlights recent findings on the role of lipid metabolism in CSCs, focusing
on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their …

It'sa lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation

E Bieberich - Neurochemical research, 2012 - Springer
… Therefore, many bioactive lipids can regulate stem cell differentiation in two different ways, …
redox potential) and lipid raft-dependent stem cell differentiation in the subsequent sections. …

The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment

F Pistollato, F Giampieri, M Battino - Food and chemical toxicology, 2015 - Elsevier
bioactive components seem to play a role. This review aims to discuss the effects elicited by
… -derived bioactive nutrients in the regulation of CSC self-renewal, cancer metabolism and …

… Stem/Stromal Cells metabolomic and bioactive factors profiles: A comparative analysis on the umbilical cord and dental pulp derived Stem/Stromal Cells secretome

AR Caseiro, S Santos Pedrosa, G Ivanova… - PLoS …, 2019 - journals.plos.org
… the metabolite profile of the collected CM and to enlighten on the metabolic pathways presiding
to the process. Further, the bioactive … expressed by pluripotent stem cells was performed. …

Identification of bioactive metabolites using activity metabolomics

MM Rinschen, J Ivanisevic, M Giera… - … reviews Molecular cell …, 2019 - nature.com
stem cells, α-ketoglutarate modulates pluripotency by promoting the activity of jumonji C (JMJC)-domain-containing
histone demethylases and the TET family of DNA demethylases, …

A rich source of potential bioactive compounds with anticancer activities by Catharanthus roseus cambium meristematic stem cell cultures

SH Moon, M Pandurangan, DH Kim… - Journal of …, 2018 - Elsevier
… The development of secondary metabolites such as alkaloids, phenolic compounds and
essential anticancer and other bioactive metabolites have been discovered by using plant cell

Tunable supramolecular hydrogels for selection of lineage-guiding metabolites in stem cell cultures

EV Alakpa, V Jayawarna, A Lampel, KV Burgess… - Chem, 2016 - cell.com
bioactive metabolites depleted during different stem cell differentiations as guided by the
materials and that the metabolites … differentiation by being fed to stem cell cultures. We thus …

Cancer stem cells: potential target for bioactive food components

YS Kim, W Farrar, NH Colburn, JA Milner - The Journal of Nutritional …, 2012 - Elsevier
… Considering the effects of vitamin A metabolites on developmental, differentiation and self-renewal
processes, the study examining the relationship between these dietary components …

Essential fatty acids and their metabolites as modulators of stem cell biology with reference to inflammation, cancer, and metastasis

UN Das - Cancer and Metastasis Reviews, 2011 - Springer
bioactive molecules that have a regulatory role in stem cell survival, proliferation, and
differentiation may aid in the use of stem cells in … kinases, and stimulate cell proliferation via Ca 2+ …