Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery A Thermodynamic and Kinetic Study

A Plantinga, A Witte, MH Li, A Harmon… - ACS medicinal …, 2011 - ACS Publications
… In an effort to develop RF antagonists for targeted drug delivery applications, we tried to
identify new RF antagonists amenable for chemical modifications to allow conjugation to …

Bioanalytical strategies in drug discovery and development

A Thakur, Z Tan, T Kameyama… - Drug Metabolism …, 2021 - Taylor & Francis
… A major requirement for bioanalysis is the ability of the bioanalytical method to accurately
detect very low concentrations of the analyte(s) of interest. For faster screening of molecules …

Rational design and functional evolution of targeted peptides for bioanalytical applications

Y Huang, Y Jin, R Zhao - Science China Chemistry, 2016 - Springer
… Concerning the bioanalytical applications, peptides are … , screening and analytical applications
of targeted peptides. … with the peptide for targeted drug delivery and retention in tumor…

NBCD pharmacokinetics and bioanalytical methods to measure drug release

VV Ambardekar, ST Stern - Non-biological complex drugs: the science and …, 2015 - Springer
… In summary, NBCD pharmacokinetics and bioanalytical methods development are an
exciting and timely area of drug delivery research. With greater regulatory scrutiny of follow-on …

Bioanalytical method development and validation: Critical concepts and strategies

MM Moein, A El Beqqali, M Abdel-Rehim - Journal of Chromatography B, 2017 - Elsevier
… Linearity evaluates the facility of the bioanalytical method to acquire test results that are
directly proportionate to the concentration of the analyte in the sample. According to FDA …

Bioanalytical assay strategies for the development of antibody–drug conjugate biotherapeutics

S Kaur, K Xu, OM Saad, RC Dere… - Bioanalysis, 2013 - Taylor & Francis
… Characterization of antibody–drug conjugate (trastuzumab emtansine) drug distribution in
a … This study showed the importance of testing the quantification of individual DARs during …

Electrochemical Protein-based Bioanalytical Devices for Drug Analysis

CG Sanz, VC Diculescu - Current Topics in Medicinal …, 2023 - ingentaconnect.com
… electrochemical drug delivery systems with anchored drugs … years on protein-based
bioanalytical devices and biosensors, … drug screening, delivery, or their metabolism, as well as …

Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum

B Buscher, S Laakso, H Mascher, K Pusecker… - Bioanalysis, 2014 - Taylor & Francis
… to the design of PPB studies and the bioanalysis of PPB samples: ‘PPB screening
experiments in (early) drug discovery versus qualified/validated procedures in drug development. …

Current direction and advances in analytical sample extraction techniques for drugs with special emphasis on bioanalysis

G Navitha Reddy, A Dilip Zagade, P Sengupta - Bioanalysis, 2019 - Taylor & Francis
… This review summarizes the suitability of application of the advanced sample preparation
techniques available for chemical and bioanalysis in a comprehensive manner. This review …

Multi-target screening of biological samples using LC–MS/MS: focus on chromatographic innovations

I Kohler, D Guillarme - Bioanalysis, 2014 - Taylor & Francis
… already been demonstrated with the analysis of drugs in biological fluids, but HILIC and
SFC approaches remain scarcely applied to multi-target screening procedures in bioanalysis. …