… concept isosterism to design bioactive molecules, … biological activity of bioreceptor, whether
through agonist or antagonist actions. However, Friedman introduced the term bioisosterism …

… Peptide isosteres have been discussed in reviews on the rational design of peptide hormones
and neurotransmitters12 and conformational restrictions of biologically active peptides.13 …

… biological activity has given rise to the term bioisosterism. As … have a similar type of biological
activity, which may even be … The critical component for bioisosterism is that bioisosteres …

… in drug design and lead optimization process as it may enhance the desired biological or …
parameters to obtain molecules having similar biological activity. Few of the popular examples …

… its biological activities, characterized as structure activity relationship (SAR) [14-15]. This
study of SAR is used in drug design … In summary, bioisosterism is a special process of rational …

… Abstract--To examine the effects of bioisosteric replacement on the biological activity of
our previously disclosed disubstituted urea inhibitors of the enzyme acyl-CoA:cholesterol …

… concept of bioisosterism can be an aid to the design of such … (B) Whether the same or a
different biological activity results … may be suggestive to the drug designer, the idea is probably …

… -linked 1,2,4-oxadiazoles were designed by means of bioisosterism. The preliminary bioassay
showed that most compounds exhibited good lethal activities against Mythimna separate, …

… bioisosterism given the similarities between the two isotopes, but there are circumstances in
drug design … to increased HLM stability but poor biological activity, attributed to the electron …

… Bioisosterism is a principle exploited in the design of … design, some applications of the
sulfoximine functionality, the … BCP is a substructure in studies with biological activity or where the …