… the development of effective VEGFR-2 inhibitors, three … evaluated in vitro for their inhibitory
activity against VEGFR-2. In particular, compounds 16k and 21d potently inhibited VEGFR-2 …

… In an effort to develop ATP-competitive VEGFR-2 selective inhibitors, a series of new … The
target compounds were biologically evaluated for their inhibitory activity against VEGFR-2. The …

… VEGFR-2/HDAC inhibitors. Compound 6fd exhibited the most potent inhibitory activity against
HDAC with IC 50 of 2.2 nM and strong inhibitory effect against VEGFR-2 … of VEGFR-2 and …

In our effort to develop potent and effective agents with anti-proliferative activity towards HepG2
hepatocellular carcinoma cells with potential inhibitory activity against VEGFR-2, a novel …

Vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibition is a well-established
strategy to promptly tackle tumor growth by suppression of angiogenesis. We report …

This study aimed to design anticancer theobromine derivatives inhibiting VEGFR-2. The new
compounds were tested in vitro to evaluate their effectiveness against MCF-7 and HepG2 …

… Vascular endothelial growth factor receptor 2 (VEGFR2) has … synthesized and evaluated for
their VEGFR2 inhibitory activity as … In vitro biological evaluations against these human tumor …

… pyrimidine derivatives as potential VEGFR-2 TK inhibitors. Observing the results of different
biological tests (in vitro anti-proliferative activity, measurement of VEGFR-2 TK activity), we …

In the current work, we designed and synthesized three families of non-fused and fused
compounds based on cyanopyridone: derivatives of 6-amino-1,2-dihydropyridine-3,5-…

… good potency against VEGFR-2 (IC50 … biological evaluations against multiple kinases (Table
2). Compounds 9d and 9o exhibited selective inhibitory activities against VEGFR-2, VEGFR-…