… to explore the impact of Akt signaling on radiation-… the PI3K/Akt pathway in the gut in vivo,
which may act as a protective mechanism. These results demonstrate the importance of the Akt …

… (PI3K)/protein kinase B (PKB, also known as AKT)/mammalian target of rapamycin (mTOR).
mTOR is involved in multiple biological … impact on MERS-CoV by inhibiting PI3K/AKT/mTOR …

… In summary, our study demonstrated that the PI3K/AKT/mTOR pathway was involved in the
development and cisplatin-based chemotherapy of ovarian cancer. Down-regulation of AKT …

Prostate and breast cancer are the two cancers with the highest incidence in men and women,
respectively. Here, we focus on the known biology of acquired resistance to antihormone …

… This study demonstrates the impact of functional components of the PI3K/Akt pathway as …
regulation of the PI3K/Akt pathway that might coincide with different tumour biology and thus …

… PI3K/Akt/mTOR signaling pathway and CSC biology. Herein, we provide a comprehensive
review on the role of signaling components upstream and downstream of PI3K/Akt/… impact the …

… The newly described SCLC subtypes are characterized by distinct biological behavior and
vulnerabilities that can be therapeutically exploited. The PI3K/Akt/mTOR pathway is frequently …

… Despite progress in the understanding of the biology of cancer, cytotoxic chemotherapy …
, their functional impact and therefore predictive value for sensitivity to PI3K inhibition is still …

… Although these concentrations are much higher than exposures achieved in man by AKT
and mTOR inhibitors of similar potency, the biology invoked as a consequence of greater target …

… and define its impact on downstream biological responses. Studies of Akt-binding molecules
… As a target of phosphoinositide 3-kinase (PI3K) (1), Akt regulates a wide range of biological …