Endoscopic tissue characterization by frequency-domain fluorescence lifetime imaging (FD-FLIM)

J Mizeret, G Wagnières, T Stepinac… - Lasers in medical …, 1997 - Springer
… Typical FLTs of biological molecules range from tens of picoseconds (ps) … Fluorescence
lifetime images of human tissue samples were successfully performed. The fluorescence lifetime

Spectral and lifetime fluorescence imaging microscopies: new modalities of multiphoton microscopy applied to tissue or cell engineering

D Dumas, N Gaborit, L Grossin, B Riquelme… - …, 2004 - content.iospress.com
Fluorescence Lifetime Imaging Microscopy, firstly to collect images based on fluorescence
lifetime … excitation which is less scattered in biological tissue, allowing deeper penetration into …

Imaging fibrosis and separating collagens using second harmonic generation and phasor approach to fluorescence lifetime imaging

S Ranjit, A Dvornikov, M Stakic, SH Hong, M Levi… - Scientific reports, 2015 - nature.com
… During this wound healing process new tissues are … matrix (ECM) in tissues and are the major
components of fibrosis 7,… for various other biological functions including tissue flexibility 8 . …

Fluorescence lifetime imaging of endogenous biomarker of oxidative stress

R Datta, A Alfonso-García, R Cinco, E Gratton - Scientific reports, 2015 - nature.com
tissues by fluorescence lifetime imaging (FLIM). We identified an autofluorescent, endogenous
species with a characteristic fluorescent lifetime … -invasive imaging of biological samples, …

Er: Yb: NaY 2 F 5 O up-converting nanoparticles for sub-tissue fluorescence lifetime thermal sensing

OA Savchuk, P Haro-Gonzalez, JJ Carvajal, D Jaque… - Nanoscale, 2014 - pubs.rsc.org
… background that can mask the signal emitted by luminescent nanoparticles and can also
damage the biological tissues. The alternative use of up-conversion nanoparticles (UCNPs), …

Fluorescence lifetime imaging microscopy: in vivo application to diagnosis of oral carcinoma

Y Sun, J Phipps, DS Elson, H Stoy, S Tinling, J Meier… - Optics letters, 2009 - opg.optica.org
… Autofluorescence of biological tissues provides abundant intrinsic signals revealing changes
in chemical composition, metabolism, and morphology [1, 2] owing to either pathologic …

Fluorescence lifetime of normal, benign, and malignant thyroid tissues

M Brandao, R Iwakura, F Basilio… - … of biomedical optics, 2015 - spiedigitallibrary.org
fluorescence lifetimes to differentiate healthy and benign tissues from malignant thyroid tissue
We observed fluorescence lifetimes at 340 nm emission of 0.80±0.26 and 3.94±0.47 ns for …

Fluorescence lifetime imaging microscopy (FLIM)

EB van Munster, TWJ Gadella - Microscopy Techniques: -/-, 2005 - Springer
… application of FLIM in cell biological en biomedical studies. Especially … biology. Other
application areas, including usage of lifetime contrast for ion-imaging, quantitative imaging, tissue

Simulations of time-resolved fluorescence in multilayered biological tissues: applications to clinical data modeling

MA Mycek, K Vishwanath, BW Pogue… - Advanced …, 2003 - spiedigitallibrary.org
… Mycek, "Quantitative fluorescence lifetime spectroscopy in turbid media: comparison of
theoretical, experimental and computational methods", Physics in Medicine and Biology, 47, 3387…

Label-free macroscopic fluorescence lifetime imaging of brain tumors

M Lukina, K Yashin, EE Kiseleva, A Alekseeva… - Frontiers in …, 2021 - frontiersin.org
… Therefore, all three tumor models showed a difference between the tumor and the healthy
brain tissue in, at least, one fluorescence lifetime parameter. The difference between the tumor …