… An ongoing clinical trial in septic shock patients stratifies the patients based on their immune
status, followed by randomization into appropriate immunotherapeutic arms: Anakinra (IL-1 …

… , anti-inflammatory, coagulation, and apoptosis pathways involved in the pathogenesis of
severe sepsis and septic shock. Analysis of the biomarkers for the purpose of this study was …

… Each of these variables can generate putative biological markers for sepsis, providing information
to one or more of the three issues: diagnostic, severity and therapy monitoring. …

… physiologic changes indicative of systemic inflammation, which are likely … biomarker for
adults with septic shock. This initial study indicates that IL-8 is not a robust stratification biomarker …

… So-called septic shock, in which patients suffer cardiovascular collapse and often are …
Therefore, many inflammatory chemokines are potential biomarkers of sepsis, and some …

… (one in the ICU, the other in the ED) observed that PCT but not CRP could distinguish
between severe sepsis and septic shock, we did not find that PCT, IL-6, or CRP could distinguish …

… inflammatory patterns early severe sepsis and septic shock ( 9 ). These studies were
conducted under the auspices of an independent, external safety and data monitoring committee …

… In patients with septic shock, alterations in inflammation, coagulation, oxidative stress,
and … of inflammatory biomarkers. The mechanisms responsible for this effect are unclear. …

… of endogenous mediators of inflammation, coagulation, and … biomarkers start at equal values,
the effect of inflammatory … Vasopressin Septic Shock Trial and a singlecenter septic shock …

… Biomarker levels in animal and human research models are elevated within 30 min after
exposure to an inflammatory septic stimulus. Consistent with these findings, the biomarker …