Predictive biomarkers for response to immune checkpoint inhibitors in lung cancer: PD-L1 and beyond

H Uruga, M Mino-Kenudson - Virchows Archiv, 2021 - Springer
… Therefore, other biomarkers have … checkpoint inhibitor (ICI) therapy in general. Of those,
TMB has been extensively studied as an alternative or complementary biomarker for response to …

Genome and transcriptome biomarkers of response to immune checkpoint inhibitors in advanced solid tumors

A Pender, E Titmuss, ED Pleasance, KY Fan… - Clinical Cancer …, 2021 - AACR
… predictors of ICI response (13, 14). Here we explored proposed biomarkers of ICI sensitivity
in a … the primary focus of this study for examining genomic biomarkers predictive of response. …

[HTML][HTML] Cancer immunotherapy with immune checkpoint inhibitors-biomarkers of response and toxicity; current limitations and future promise

B Healey Bird, K Nally, K Ronan, G Clarke, S Amu… - Diagnostics, 2022 - mdpi.com
… profiling, and liquid biomarkers such as systemic inflammatory … outcome and its use as a
biomarker of response and toxicity. … and future biomarkers of response, resistance and toxicity. …

The genomic landscape of Merkel cell carcinoma and clinicogenomic biomarkers of response to immune checkpoint inhibitor therapy

TC Knepper, M Montesion, JS Russell, ES Sokol… - Clinical Cancer …, 2019 - AACR
… other potential biomarkers of immunotherapy response, we … PD-L1, positivity, and
immunotherapy response. This finding … exhibit similar response rates to checkpoint inhibitor

[HTML][HTML] Biomarkers for predicting the efficacy of immune checkpoint inhibitors

C Wang, H Wang, L Wang - Journal of Cancer, 2022 - ncbi.nlm.nih.gov
response to PD-1 inhibitors, which limited the clinical applications of anti-PD-1/PD-L1 therapy
5 . Predictive biomarkers … This article reviewed current potential biomarkers by categories …

Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non–small cell lung cancer

K Shien, VA Papadimitrakopoulou, II Wistuba - Lung Cancer, 2016 - Elsevier
… with outcomes of immune checkpoint inhibition. Here, we review the reported predictive
biomarkers of response to PD-1 pathway immune checkpoint inhibitors in NSCLC, mainly …

[HTML][HTML] New biomarkers for checkpoint inhibitor therapy

N Burdett, J Desai - ESMO open, 2020 - Elsevier
… likelihood of response. There is a wide range of methodologies investigating predictive
biomarkers in this space; in this review, we address the major putative biomarkers of interest. …

Predictive biomarkers for checkpoint inhibitor-based immunotherapy

GT Gibney, LM Weiner, MB Atkins - The Lancet Oncology, 2016 - thelancet.com
… emerging data on new biomarker strategies with tumour-… effective predictive biomarker
for checkpoint inhibitor-based … of biomarkers as aids to checkpoint inhibitor immunotherapy …

Clinical and Molecular Characterization of POLE Mutations as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers

B Garmezy, J Gheeya, HY Lin, Y Huang, T Kim… - JCO Precision …, 2022 - ascopubs.org
… appropriate predictive biomarkers of response to optimize patient selection for immune
checkpoint inhibitor (ICI) therapy remains a challenge. The programmed death 1 (PD-1) inhibitor

[HTML][HTML] T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors

T Yamauchi, T Hoki, T Oba, V Jain, H Chen… - Nature …, 2021 - nature.com
… circulating T-cell biomarker, we analyze … response to anti-PD-1 therapy. Our results support
circulating CX3CR1 + CD8 + T cells as an early on-treatment biomarker of clinical response