… bisindole hybrids in the development of novel anticancer agents. In this review, we present a
brief account of the bisindole alkaloids … anticancer activity developed in the recent 10 years. …

… compounds have been isolated with to the anticancer activities proved. In this paper, we
review the progress of bisindole alkaloids with the potential anticancer value extracted from …

… tinctoria L, has already been used in clinical practice for the treatment of chronic myeloid
leukemia, revealing the potential of bisindole alkaloids as putative anticancer agents [77, 78]. …

… of new anticancer therapeutics. In this work, the anticancer activity of indole and bisindole
alkaloids … Aiming at summarizing our contribution in the study of these species, the anticancer …

… A random screening of botanical sources for anticancer activity showed that the aqueous
alcoholic extract of the roots of Tabernaemontana holstii K. Schum (family Apocynaceae) gave …

… indole alkaloids with high anticancer activity to seek for more promising preclinical/clinical
candidates; (3) modification of the lead hits to obtain novel agents with enhanced activity. …

… Vinblastine (117) and vincristine, well-known antitumor bisindole alkaloids, are biogenetically
derived from the coupling of vindoline (123, Aspidosperma type) and catharanthine (124, …

… to their activities as cerebral vasodilators, anticancer agents, … and biological activities of
new indoles alkaloids. Databases, … New bisindole alkaloids have also been isolated in the last …

… bisindole alkaloids as Wnt signaling inhibitor by using a cell-based luciferase assay system,
among which, Bisleuconothine A (BLA) showed the most potent activity. … anti-tumor activity in …

… In general, aromatic substitution of the bisindole nucleus results in reduced antitumor activity.
12’, 17-Dibromovinblastine (6) shows approximately one-tenth the potency of vinblastine in …