… found alkaloids displayed potent anticancer activity both in vitro and in vivo, and some of the
anticancer alkaloids … Indole-carbazole alkaloids belong to bisindole alkaloids derived from L-…

… , anticancer activities and structure and activity relationship (SAR) was investigated. Compounds
7a, 7c and 8a were found to be active in antimicrobial screening. Anticancer screening …

… , anticancer, antidiabetic, and antiparasitic activities. This … m yielded two chlorinated bis-indole
alkaloids, dienomycin (119) … ZZ1275 also furnished a bis-indole alkaloid indolepyrazine A (…

… Most of the 3,5-bis(indolyl)-1,2,4-thiadiazoles exhibited pronounced antitumor activity …
showed comparable anticancer activity. Further study to improve the anticancer activity and …

… for future anticancer drug lead. … anticancer activities than those recognized from A.
penangiana, although all of them belong to macroline- and akuammiline-type bisindole alkaloids. …

… Rhopaladins are another class of related bisindole alkaloids from tunicates. Some of these
… ,11 antitumor, 4 antiviral, 4 antifungal, 3,6 antibacterial, 8,9 and anti-inflammatory activities. A …

… anticancer studies [57]. Cisplatin was used as reference … bisindoles can inhibit MARK4
activity. Further expansion of this approach can be envisaged for the modification of the bisindole …

… bisindole compounds due to the lack of a central heterocyclic ring, which is instead opened
in 1 and 2. As the tryptophan origin of bisindole alkaloids … family of bisindole alkaloids that …

… The compound identified as bisindole alkaloid ochrolifuanine using Nuclear Magnetic …
known as anti-cancer agent was shown to have a lethal effect on T. brucei, T. cruzi and L. …

… sources, antitumour activity, and clinical pharmacology of various alkaloids are discussed, …
it is the first synthesis of a bisindole alkaloid from Alstonia species. The protected macroline …