过去一年中添加的文章,按日期排序

Interaction of norsecurinine-type monomeric and dimeric alkaloids with α-tubulin: A molecular docking study

G Vergoten, C Bailly - Exploration of Drug Science, 2024 - explorationpub.com
31 天前 - alkaloid formed more stable complexes with tubulin than the monomeric counterparts,
such as fluevirines B–D. The bis-indole … penetration and robust antitumor activity alone or …

Globospiramine from Voacanga globosa Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 …

JAH Manzano, EA Abellanosa, JP Aguilar, S Brogi… - Cells, 2024 - mdpi.com
52 天前 - Bisindole alkaloids are a source of inspiration for the design and discovery of
new-generation anticancer … In addition, natural compounds with promising anticancer activities are …

Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species

BMF Gonçalves, N Duarte, C Ramalhete… - Phytochemistry …, 2024 - Springer
56 天前 - anticancer therapeutics. In this work, the anticancer activity of indole and bisindole
alkaloids … study of these species, the anticancer evaluation of two sets of monoterpene indole …

Characterization of a CrPME indicates its possible role in determining vindoline accumulation in Catharanthus roseus leaves

P Singh, S Yadav, S Shah, K Shanker… - Physiologia …, 2024 - Wiley Online Library
114 天前 - … over 130 terpenoid indole alkaloids (TIAs) (Shukla and Khanuja, 2013). It is well
known for its highly priced and scarce anticancer bisindole alkaloids, vinblastine and vincristine…

Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development

M Xu, Z Bai, B Xie, R Peng, Z Du, Y Liu, G Zhang… - Molecules, 2024 - mdpi.com
122 天前 - … progress on marine bisindole alkaloids and their derivatives with anticancer activity.
… The in vitro antitumor activities of these compounds against 10 human tumor cells were …

Chemical Composition and Antioxidant Activity of the Essential Oil of Tabernaemontana dichotoma

WMNHW Salleh, MH Arzmi, S Khamis… - Chemistry of Natural …, 2024 - Springer
144 天前 - … dichotoma to be a source of novel structured indole and bis-indole alkaloids
possessing interesting bioactivities, with most notably anticancer properties [7,8,9,10,11]. The …

Vincamine, from an antioxidant and a cerebral vasodilator to its anticancer potential

Y Ren, K DeRose, L Li, JC Gallucci, J Yu… - Bioorganic & Medicinal …, 2023 - Elsevier
318 天前 - … Vinorelbine (9) (Navelbine®) is a third-generation of Vinca alkaloid that suppresses
… more potent antitumor activity than other previous bisindole alkaloid anticancer agents and …

Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells

MZ Al-Hayali, CE Nge, KH Lim, HM Collins, TS Kam… - Molecules, 2024 - mdpi.com
336 天前 - … In conclusion, broad-spectrum, potent antitumour activity by bisindole alkaloid
conofolidine isolated from Tabernaemontana corymbosa has been described. Cancer cell growth …