Bloodbrain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

MD Sweeney, AP Sagare, BV Zlokovic - Nature Reviews Neurology, 2018 - nature.com
… the brain of neurotoxic blood-… brain and post-mortem tissue as well as biomarker studies
demonstrating BBB breakdown in Alzheimer disease, Parkinson disease, Huntington disease, …

[HTML][HTML] The blood-brain barrier in Alzheimer's disease

E Zenaro, G Piacentino, G Constantin - Neurobiology of disease, 2017 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the …
brain inflammation, which promotes disease pathogenesis. In this context, the blood-brain barrier …

The amyloid precursor protein of Alzheimer disease in human brain and blood

QX Li, SJ Fuller, K Beyreuther… - Journal of leukocyte …, 1999 - academic.oup.com
… genic mice, and post-mortem brain tissue have advanced our understanding of Alzheimer
disease (AD). However, the molecular pathogenesis of the disease is still not clear, and we …

Disruption of blood-brain barrier in Alzheimer disease pathogenesis

SY Kook, H Seok Hong, M Moon, I Mook-Jung - Tissue barriers, 2013 - Taylor & Francis
Blood-brain barrier (BBB) regulates transport of various molecules and maintains brain
have been implicated in the pathogenesis of Alzheimer disease (AD). Although receptor for …

[HTML][HTML] Bloodbrain-barriers in aging and in Alzheimer's disease

F Marques, JC Sousa, N Sousa, JA Palha - Molecular neurodegeneration, 2013 - Springer
diseases of the CNS, such as multiple sclerosis and AD, changes in blood composition,
brain inflammation and the facilitated entrance of immune cells through the brain barriers can …

Bloodbrain barrier impairment in Alzheimer disease: stability and functional significance

GL Bowman, JA Kaye, M Moore, D Waichunas… - Neurology, 2007 - AAN Enterprises
… Conclusions: Bloodbrain barrier (BBB) impairment is a stable characteristic over 1 year
and present in an important subgroup of patients with Alzheimer disease. Age, gender, APOE …

Blood-brain barrier leakage in patients with early Alzheimer disease

HJ Van De Haar, S Burgmans, JFA Jansen… - Radiology, 2016 - pubs.rsna.org
Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating substances
in patients with early forms of Alzheimer disease (AD), and if so, to examine the extent …

Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease

R Deane, BV Zlokovic - Current Alzheimer Research, 2007 - ingentaconnect.com
blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's
disease … Amyloid-β peptide as a vaccine for Alzheimer's disease involves receptor-mediated …

Bloodbrain barrier dysfunction as a cause and consequence of Alzheimer's disease

MA Erickson, WA Banks - Journal of Cerebral Blood Flow & …, 2013 - journals.sagepub.com
The bloodbrain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases, …

Role of blood-brain barrier in Alzheimer's disease

Z Cai, PF Qiao, CQ Wan, M Cai… - … of Alzheimer's Disease, 2018 - content.iospress.com
The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer’s disease (AD).
BBB is a highly selective semipermeable structural and chemical barrier which ensures a …