Biphasic opening of the blood-brain barrier following transient focal ischemia: effects of hypothermia

ZG Huang, D Xue, H Karbalai, AM Buchan… - Canadian journal of …, 1999 - cambridge.org
… six hours of reperfusion prevented opening, reducing Ki by … a marked biphasic opening of
the cortical blood-brain barrier, the … volume and the late opening of the blood-brain barrier. This …

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion

T Kuroiwa, P Ting, H Martinez, I Klatzo - Acta neuropathologica, 1985 - Springer
… The first opening, occurred shortly after recirculation; this was associated with rCBF below …
BBB opening in these animals was confirmed by the PAP staining. The second opening of the …

The biphasic opening of the bloodbrain barrier in the cortex and hippocampus after traumatic brain injury in rats

MK Başkaya, AM Rao, A Doğan, D Donaldson… - Neuroscience …, 1997 - Elsevier
… that the BBB opening occurs in a biphasic pattern after CCI brain injury. The first opening
appears to … At 3 days, a second prominent opening of the BBB occurred and this increase was …

Cerebral ischemia–reperfusion injury in rats—A 3 T MRI study on biphasic bloodbrain barrier opening and the dynamics of edema formation

DR Pillai, MS Dittmar, D Baldaranov… - … of Cerebral Blood …, 2009 - journals.sagepub.com
… between the biphasic opening of BBB and the dynamics of brain water … , blood oxygenation
level dependant effects and effects of inhalational anesthetics. The biphasic BBB opening

Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain

GA Rosenberg, EY Estrada, JE Dencoff - Stroke, 1998 - Am Heart Assoc
… The delayed opening, which was associated with elevated levels of … different mechanisms
of injury for the biphasic BBB injury. … Reperfusion causes a biphasic opening of the blood-brain

The bloodbrain barrier is continuously open for several weeks following transient focal cerebral ischemia

D Strbian, A Durukan, M Pitkonen, I Marinkovic… - Neuroscience, 2008 - Elsevier
… reperfusion injury has long been considered to be biphasic, although a considerable amount
of discrepancies as for the timing of the second opening does exist among the studies. This …

Blood-brain barrier breach following cortical contusion in the rat

SA Baldwin, I Fugaccia, DR Brown, LV Brown… - Journal of …, 1996 - thejns.org
… 2 days after cortical contusion, indicating a biphasic opening of the BBB following head
trauma and a possible second wave of secondary brain damage days after the contusion injury. …

Three openings of the blood-brain barrier produced by forebrain ischemia in the rat

E Preston, G Sutherland, A Finsten - Neuroscience letters, 1993 - Elsevier
… , have reported biphasic opening of the BBB which may reflect events equivalent to the first
and third opening observed in the present work. An early hemodynamic opening followed by …

Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrest

R Pluta, AS Lossinsky, HM Wis, MJ Mossakowski - Brain research, 1994 - Elsevier
… disturbance [31] and a restricted breakdown of the BBB represented as a biphasic opening
of the barrier at vessel bifurcations observed in cerebral ischemia induced by cardiac arrest. …

Post-ischemic bloodbrain barrier leakage in rats: one-week follow-up by MRI

A Durukan, I Marinkovic, D Strbian, M Pitkonen… - Brain research, 2009 - Elsevier
… We therefore aimed to reevaluate the presumed pattern of biphasic BBB opening following
transient cerebral ischemia by a quantitative and longitudinal MRI approach. For this, we …