Can natural products exert neuroprotection without crossing the bloodbrain barrier?

M Leclerc, S Dudonné, F Calon - International Journal of Molecular …, 2021 - mdpi.com
… focusing on two classes of natural products: omega-3 … of a natural product with relatively high
brain bioavailability … as an example of natural compounds with low brain bioavailability, yet …

The protective effects of natural products on blood-brain barrier breakdown

A Kam, KM Li, V Razmovski-Naumovski… - Current medicinal …, 2012 - ingentaconnect.com
… Therefore, whether the natural products covered in the present review are also effective
in maintaining the vascular integrity of other blood-endothelial barriers and their related …

Drug interactions with natural products at the blood brain barrier

G Fricker - Current drug metabolism, 2008 - ingentaconnect.com
… of blood brain barrier and CNS safety related considerations on natural products deserve …
studies show direct effects of herbal products on the blood brain barrier. However, one has to …

[HTML][HTML] Remodeling the bloodbrain barrier microenvironment by natural products for brain tumor therapy

X Zhao, R Chen, M Liu, J Feng, J Chen, K Hu - Acta pharmaceutica sinica B, 2017 - Elsevier
… of natural products are reported to regulate the BBB microenvironment near brain tumors
and … the BBB microenvironment by natural products to promote the treatment of brain tumors. …

Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier

Y Li, T Chen, X Miao, X Yi, X Wang, H Zhao… - Pharmacological …, 2017 - Elsevier
… the passage of substances from the blood into the brain and other parts of the … natural
products and nanosized drug delivery systems across the BBB. Due to the highly conserved nature

Applicability of a bloodbrain barrier specific artificial membrane permeability assay at the early stage of natural product-based CNS drug discovery

A Könczöl, J Müller, E Földes… - … of natural products, 2013 - ACS Publications
… the bloodbrain barrier (PAMPA-BBB) for natural products and … power in the case of natural
products and provides high … tool in terms of selecting brain-penetrable compounds from plant …

In silico modeling on ADME properties of natural products: Classification models for blood-brain barrier permeability, its application to traditional Chinese medicine …

X Zhang, T Liu, X Fan, N Ai - Journal of Molecular Graphics and Modelling, 2017 - Elsevier
In silico modeling of blood-brain barrier (BBB) permeability plays an important role in early
discovery of central nervous system (CNS) drugs due to its high-throughput and cost-…

Rapid screening of brain-penetrable antioxidants from natural products by blood-brain barrier specific permeability assay combined with DPPH recognition

J Zhu, X Yi, J Zhang, S Chen, Y Wu - Journal of Pharmaceutical and …, 2018 - Elsevier
Screening brain-penetrable antioxidants from natural products is a promising way for
neuroprotective drug discovery. However, there is no screening methodology enables …

Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm

ER Gerstner, RL Fine - Journal of clinical oncology, 2007 - ascopubs.org
… is that metastatic brain tumors … to natural product chemotherapy drugs than gliomas. This
information could lead to a paradigm shift in the use of natural product drugs for metastatic brain

Bloodbrain barrier permeability study of potential neuroprotective compounds recovered from plants and agri-food by-products

JD Sánchez-Martínez, A Valdés, R Gallego… - Frontiers in …, 2022 - frontiersin.org
… reported for some natural compounds, it is crucial to demonstrate their permeability across
the bloodbrain barrier (BBB) to guarantee that they can reach brain tissues and exert the …