… The physiological role of muscarinic acetylcholine receptors expressed by pancreatic b …
the M3 muscarinic acetylcholine receptor subtype in pancreatic b cells display impaired glucose …

… The release of insufficient amounts of insulin in the presence of elevated blood glucose
levels is one of the key features of type 2 diabetes. Various lines of evidence indicate that …

… To examine whether the lack of hepatic M 3 receptors … in blood glucose levels over a 2-h
period (pyruvate challenge test) (21). We found that the observed increases in blood glucose …

… To examine the relevance of β-cell M 3 mAChRs in maintaining normal blood glucose levels
in vivo, we generated mutant mice lacking M 3 receptors selectively in pancreatic β-cells (β-…

… or no effect on blood glucose and insulin levels, but it restored wild type-like blood glucose
and insulin levels to the mutant animals, which had exhibited reduced blood glucose and …

… To examine whether M 3 receptor mutant mice showed altered blood glucose and insulin
levels, we continuously monitored these parameters in freely fed WT, M3 +/− , and M3 −/− mice …

… levels, saline, nicotine, or CSM were injected and basal blood glucose levels (from tail bleed)
were determined 30 minutes after agonist treatment. CSM treatment (15 min) was initiated …

… Previous studies have shown that β-cell M 3 muscarinic acetylcholine receptors (M3Rs)
play a key role in maintaining blood glucose homeostasis by enhancing glucose-dependent …

… Blood glucose concentrations were measured at the indicated time points. Mice with blood
glucose … to the GTT to evaluate their response to ip injected glucose (2 g/kg body weight) …

… We report that GTS-21 lowers levels of blood glucose in obese, hyperglycaemic, leptin
receptor-deficient db/db mice, a model system for drug discovery relevant to the treatment of …