… hallmark of Parkinson’s disease (PD) is the presence of fibrillar aggregates referred to as
Lewy bodies (LBs), in which α-synuclein is a major constituent. Pale bodies, the precursors of …

… Individuals with isolated RBD have an increased risk of developing a neurodegenerative
disease (including Parkinson's disease, Lewy body disease, multiple system atrophy): 18–35% …

… of cortical Lewy bodies occur in idiopathic Parkinson’s disease and the incidental Lewy
body Disorder. There is also an unusual syndrome of diffuse cortical Lewy bodies that are …

… that Parkinson's disease (PD) patients exhibit lower body weight when compared to age-matched
healthy subjects. Low body … stages of the disease. We therefore recommend that the …

… Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder
characterized by a profound and selective loss of nigrostriatal dopaminergic neurons. Clinical …

… Parkinson's disease is a common progressive bradykinetic disorder that can be accurately
diagnosed. It is characterised by the presence of severe pars-compacta nigral-cell loss, and …

… Although Lewy bodies are highly characteristic, they are not pathognomonic for Parkinson's
disease. The Lewy body type is the classical Parkinson's disease and is by far the most …

… Figure 21.5 Scheme of the hypothetical progression pathways and stages of Lewy body (LB)
disorders. The pathway for Parkinson ’ s disease (PD) is suggested to proceed through …

… Generally, postural dysfunction induces clinical impairment at the latest stages of the
disease, except in late-onset idiopathic Parkinson’s disease and in atypical parkinsonian …

… Dementia occurs more commonly in Parkinson's disease (PD) than in the age-matched
general population; estimates of prevalence are between 20% and 45%, depending on the …