… regulator of bone formation. Therefore, studies to define the agents that regulate PDGF-AA
synthesis in bone cells are critical to our understanding of its role in bone cell function. …

… of PDGF from tissue … PDGFAA from bone cell-conditioned medium and its sensitive
measurement by RIA. This technique was used to quantitate PDGF-AA production by Ob cell cultures …

… on fibroblasts, as their LI was increased up to 3-fold by PDGFAA and up to 5.5-fold with
PDGF-BB (Fig. 3). The effects on the other … growth factor AA in bone cell cultures. Endocrinology …

… cells in developing bone tissue. Using an in vitro model, the effect of PDGF-AA on the cells
… i) control group, with cells cultured in 199 medium for another 24 h; (ii) PDGF-AA group, with …

… studies were undertaken to examine the effects of bFGF, TGFP,, PDGF AA, and PDGF BB
on IGF-I transcript and polypeptide levels in cultures of Ob cells from fetal rat parietal bone. …

… physiological model to study bone healing. The results obtained indicate that PDGF AA, BB
and AB … These cells express IGF-I-binding sites and IGF-I-treated cell lines display a dose-…

… Cell cultures. Normal human adult … containing culture medium for Z4 wk to allow explanation
of bone cells. … of osteoblastic cells to PDGFAA by decreasing the binding of PDGF-AA to its …

… Platelet-derived growth factor-AA (PDGF-AA) has been reported to enhance bone tissue
remodeling by promoting cell … , the MLO-Y4 cells were seeded in glass bottom cell culture dish (…

… organ culture model, Hock and Canalis (16) observed that PDGF enhances bone cell replication
and DNA synthesis but that PDGF … growth factor-I in bone cell cultures. Endocrinology …

… that bone-derived PDGF-AA might … PDGF-AA originated from bone cells is partly in accordance
with the study by Xie et al. [13] that PDGF-BB is secreted mainly by preosteoclast in bone. …