… bone at the joint margins’. It remains an open question whether the initial changes take
place in cartilage or bone or … relationship between these changes is (5–19). Also, within each …

… articular cartilage degeneration and subchondral bone changes; early degenerative changes
… increased subchondral bone density 56 . We therefore investigated whether the degree of …

… between ligament degeneration, synovitis, joint cartilage degradation, and dysbalanced …
bone remodeling. Various features of ligament degeneration accompanying joint cartilage …

… differences in the cartilage tissue matrix, and its interface with the underlying bone, would
result in … METHODS: For this study a range of cartilage-on-bone samples, from intact to mildly …

… environment and to reciprocal changes in the other tissue. … cartilage degeneration is reduced
when subchondral bone … bone properties can affect the state of articular cartilage (31, 32). …

… : degeneration of articular cartilage, synovial immunopathogenesis, and changes in subchondral
bone. For … , degeneration of articular cartilage, and subchondral bone remodeling can …

… and shear stress towards articular cartilage, thus facilitating cartilage degeneration (108). …
in the subchondral bone plate of OA, interaction between bone and cartilage is strengthened (…

… that progression of cartilage degeneration leads to changes in bone parameters which …
bone changes in OA correlate directly with the grade of articular cartilage degeneration. The …

… articular cartilage degeneration and subchondral bone changes … Changes in subchondral
bone were less affected by the … The resorption of subchondral bone was promoted in the ACL-…

… cartilage templates of the future long bones change in size and shape and are gradually
replaced by bone … bones. About 7 weeks after fertilization and just prior to the first appearance of …