… The purpose of the study reported here was to evaluate and correlate patterns of subchondral
bone density and articular cartilage degeneration (derived by use of gross, histologic, and …

… Changes in subchondral bone in these mice are similar to those found in surgically induced
… signaling pathways are required for endochondral bone development. However, whether β-…

… This review discusses the pathomechanisms that lead to articular cartilage and bone …
degeneration and a GAG decrease early in the process of cartilage degeneration [30, 33]. In …

… is described as an isotropic material, we found that the maximal shear stresses at the
cartilage–bone interface increased by 140% after meniscectomy. According to Kelly and O’Conner (…

… in the underlying bone. Although … bone remodeling and cartilage degeneration will help
develop a therapeutic loading strategy that prevents bone loss and cartilage degeneration…

… of adult cartilage as distinct from the changes that accompany … aging changes, degeneration,
and degenerative joint disease… the junction of articular cartilage, bone, and capsular tissue. …

… tool for following degenerative joint disease progression in a given animal by detecting
changes to the cartilage/bone interface and articular cartilage. © 2006 Orthopaedic Research …

… In summary, the shift in thinking about OA as a degenerative disease of cartilage to one
of a dynamic pathology process involving all of the tissues of the joint is an important step …

… wear and tear, bone changes and changes in the cartilage extracellular matrix. Changes in
… of the growth plate of long bones, but other phenotypic changes are also reported 1 . In this …

… theories that regard the cartilage 2 , the bone 3 or both tissues in terms … to evaluate both
cartilage and bone may provide better … Radiographic articular bone changes in OA follow typical …