… degenerated than the other regions of the knee, and bone exposure may develop in the patella
independently of changes … that while the onset of cartilage changes is variable, once it is …

… In the deep zone, adjacent to the zone of calcified cartilage and subchondral bone, the
collagen fibers are larger and form bundles which are oriented perpendicular to the bone, and …

… stimulating cartilage repair and remodeling include alteration of the loading on degenerated
… ), introduction of new cartilage-forming cells by perforation of subchondral bone, and soft-…

… bone plays a significant role in the cartilage degeneration in OA (Burr, 1998). Whether the
initial changes in OA occur first in cartilage or first in the subchondral trabecular bone remains …

… bone changes occur earlier than cartilage deterioration. This finding suggests a temporal
relationship between the changes in bone and cartilage … overlying cartilage from degeneration. …

… a degenerative joint disease characterized by progressive loss of cartilage, changes in
subchondral bone… joint with changes noted in the cartilage, meniscus, synovium and subchondral …

… of cartilage and bone physiology, as well as the complex cellular processes involved in
the cartilage to bone … Osteoarthritis is a degenerative joint disease and a massive world-wide …

… reactive changes in the subchondral bone, showing the effect of cartilaginous degeneration
… , our findings suggest that the initial changes occur around the tidemark and the …

… degenerative lesions. Furthermore, we need to identify trigger mechanisms that start generalized
loss of cartilage matrix, and induce subchondral bone changes … in degenerative ageing …

… The early involvement of pathological bone degeneration identified in this study has to our
… of very early bone pathology could be due to a direct effect of blood on bone homeostasis. …