Reversing bone loss by directing mesenchymal stem cells to bone

W Yao, M Guan, J Jia, W Dai, YAE Lay… - Stem …, 2013 - academic.oup.com
… Mesenchymal stem cells (MSCs) are multipotent cells present in bone marrow that have
the potential to differentiate into osteoblasts and form bone [[3]]. Aging is associated with a …

Bone loss and its management in long-term survivors from allogeneic stem cell transplantation

L Tauchmanovà, A Colao, G Lombardi… - The Journal of …, 2007 - academic.oup.com
… Multiple risk factors for posttransplant bone loss have been recently identified: … stem cell
compartment. Pamidronate was partially successful in preventing posttransplant bone loss, …

Bone loss following hematopoietic stem cell transplantation: a long-term follow-up

CMS Schulte, DW Beelen - Blood, 2004 - ashpublications.org
Transplantation-associated bone loss is a well-known phenomenon, however, effects of
hematopoietic stem cell transplantation are insufficiently characterized. We conducted a …

Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation

PR Ebeling, DM Thomas, B Erbas… - Journal of Bone and …, 1999 - academic.oup.com
… the rate of bone loss at the FN was greater (9%/10 g of prednisolone). Bone loss was also
… In conclusion, BMT recipients are at risk of osteoporosis secondary to bone loss associated …

Bone loss in long-term survivors after transplantation of hematopoietic stem cells: a prospective study

C Schulte, DW Beelen, UW Schaefer, K Mann - Osteoporosis international, 2000 - Springer
… Our data demonstrate rapid bone loss in patients undergoing transplantation of hematopoietic
stem cells. Bone turnover is characterized by biochemical uncoupling of …

Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes

F Lei, M Li, T Lin, H Zhou, F Wang, X Su - Acta biomaterialia, 2022 - Elsevier
bone loss in periodontitis. Exosomes emerge as essential paracrine factors of mesenchymal
stem cells (… periodontal ligament stem cells (PDLSCs) as therapeutics for the bone defect in …

[HTML][HTML] Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss

I Bellantuono, A Aldahmash, M Kassem - Biochimica et Biophysica Acta …, 2009 - Elsevier
… Age related bone loss is one of the most prevalent diseases in the elder … bone homeostasis
with age. In this review we summarize evidence of MSC involvement in age related bone loss

Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass

M Guan, W Yao, R Liu, KS Lam, J Nolta, J Jia… - Nature medicine, 2012 - nature.com
… To determine whether LLP2A-Ale could prevent bone loss in a disease state, we treated
10-week-old ovariectomized (OVX) mice with PBS, Ale, LLP2A, LLP2A-Ale or parathyroid …

[HTML][HTML] Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice

YJ Lv, Y Yang, BD Sui, CH Hu, P Zhao, L Liao… - Theranostics, 2018 - ncbi.nlm.nih.gov
… functional fate decisions of stem cells, including osteogenesis and … stem cell function in
aging, according to the above information and based our previous work basis, we selected bone

Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition

W Sun, W Qiao, B Zhou, Z Hu, Q Yan, J Wu, R Wang… - Metabolism, 2018 - Elsevier
… Sirtuin 1 (Sirt1) haploinsufficiency results in a bone loss by decreased bone formation;
however, it is unclear whether Sirt1 overexpression in mesenchymal stem cells (MSCs) plays an …