… ; Lu et al., 2017; Zhang et al., 2016), we hypothesized that the subchondral bone
sclerosis of PTOA may be derived from the PI3K/AKT over-activation in the preosteoblasts/osteoblasts. …

… Additionally, blocking PI3K/AKT signaling with LY294002 reduces bone sclerosis in
subchondral bone, and delays post-traumatic osteoarthritis 71 . Apart from well characterized …

… bone formation. These results reveal that further exploration on the inhibitors of the PI3K/Akt
signaling pathway related to bone … Blocking PI3K/AKT signaling inhibits bone sclerosis in …

… Although WT mice showed marked cutaneous sclerosis with increased expression of … -mediated
PI3K/Akt signaling either with anti-αv functional blocking antibody or with the PI3K/Akt …

… bone sarcoma that occurs predominantly in children and adolescents, comprising approximately
20% of all bone … Akt can phosphorylate tuberous sclerosis complex (Tsc) 2, a tumor …

… Loss of function of Fbn1 induced a bone disorder involving elongated bone length and … To
further confirm that the IL4–IL4Rα pathway activates mTOR signaling, we performed a dosage …

… We used Western blot to determine protein expression of p-Akt and Akt in renal tissues. …
VEGF-induced angiogenesis is mediated through activating PI3k-Akt signaling pathway. …

… bone marrow-derived fibroblasts recruited into various fibrotic lesions. Mice were engrafted
with bone … directly phosphorylates and thereby inhibits tuberous sclerosis protein 1/2 (TSC1/2…

… effector of the PI3K/AKT signaling pathway. mTOR exists as two … via AKT-mediated inhibition
of tuberous sclerosis complex 1 … (B) Bony overgrowth with ulnar deviation of his bilateral 2nd …

… changes of subchondral bone may be the initiation of OA (20). In fact, the abnormally
proliferating osteoblasts in OA are closely related to subchondral bone sclerosis, inflammation, and …