Hwan D. Kim and co-workers describe bone tissue engineering strategies based on biomimetic materials. In particular, latest findings on the role of biomimetic inorganic materials for phenotypically stable bone tissue formation and osteogenic differentiation are presented in article number 1700612. Furthermore, fabricated scaffold designs and compositions that provide an osteo-friendly environment for the osteogenic commitment of stem cells are important for successful bone tissue regeneration. This Progress Report revisits various strategies to engineer three-dimensional porous structures for stem cell infiltration, vascularization, and nutrient differentiation.