… botulinum neurotoxins… botulinum neurotoxins as inhibitors of intercellular communication,
and highlight the general concept of deriving novel therapeutic molecules from the neurotoxins…

… , botulinum neurotoxins enter the neuron and causes a sustained inhibition of synaptic
transmission. The active neurotoxin is part of a high-molecular-weight complex that protects the …

… It is also the natural target of botulinum neurotoxins (BoNTs) causing a selective blockade
of … The scope of this review is to describe the principal steps implicated in botulinum toxin …

… the development of therapeutic neurotoxins. Here, we report a two-component signal
transduction system that negatively regulates botulinum neurotoxin production. Understanding the …

… Transduction and processing of these stimuli at the conscious level produce the sensation
of pain. Signal transduction happens at the free nerve ending, which is made of different fibers…

… The altered genes were mainly involved in signal transduction, immunity and defense,
protein metabolism and modification, neuronal activities, intracellular protein trafficking, and …

… Botulinum neurotoxins (BoNT) cause the disease botulism, a flaccid paralysis of the muscle.
… proteins as progenitor toxin complexes (PCT) by Clostridium botulinum to become highly …

… BT is produced by Clostridium botulinum and consists, as shown in table 1, of a complex …
containing botulinum neurotoxin and various non-toxic proteins. Botulinum neurotoxin consists …

… action of the neurotoxins (BoNT) purified from the toxin complex. … botulinum toxin, otherwise
we will precise botulinum toxin complex (ie, BoNT plus ANTPs) in opposition to neurotoxin …

… In addition, six phylogenetically distinct clostridia produce more than 40 different botulinum
neurotoxins (BoNTs) (Box 1). BoNTs consist of three primary domains: two of these domains …