JAK–STAT pathway targeting for the treatment of inflammatory bowel disease
A Salas, C Hernandez-Rocha, M Duijvestein… - Nature reviews …, 2020 - nature.com
… disease is driven by multiple immune pathways, it … –STAT signalling and the pathways
relevant to intestinal homeostasis and pathology that provide the rationale for JAK–STAT pathway …
relevant to intestinal homeostasis and pathology that provide the rationale for JAK–STAT pathway …
Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease
… through the JAK/STAT pathway and regulate the … /STAT signaling pathways also have
been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (…
been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (…
Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease
L Wang, Y Hu, B Song, Y Xiong, J Wang, D Chen - Inflammation Research, 2021 - Springer
… Majority of cytokines exert their functions through the JAK/STAT pathway, and contribute to
the … operation and interaction of various intestinal cells in IBD through the JAK/STAT pathway. …
the … operation and interaction of various intestinal cells in IBD through the JAK/STAT pathway. …
Signaling pathways associated with inflammatory bowel disease
J Wei, J Feng - Recent patents on inflammation & allergy drug …, 2010 - ingentaconnect.com
… (JAK/STAT pathway will be described below) Finally, antiapoptotic proteins and pro-… Role
of the JNK signal transduction pathway in inflammatory bowel disease. World J Gastroenterol …
of the JNK signal transduction pathway in inflammatory bowel disease. World J Gastroenterol …
Phytochemicals targeting JAK–STAT pathways in inflammatory bowel disease: Insights from animal models
SY Moon, KD Kim, J Yoo, JH Lee, C Hwangbo - Molecules, 2021 - mdpi.com
… This review describes the significance of the JAK–STAT pathway as a current therapeutic …
can ameliorate disease symptoms by affecting the JAK–STAT pathway in vivo in IBD disease …
can ameliorate disease symptoms by affecting the JAK–STAT pathway in vivo in IBD disease …
JAK-STAT pathway regulation of intestinal permeability: pathogenic roles and therapeutic opportunities in inflammatory bowel disease
H Lei, MS Crawford, DF McCole - Pharmaceuticals, 2021 - mdpi.com
… trigger disease activity in chronic inflammatory bowel disease (… other inflammatory diseases,
including celiac disease and … to the JAK-STAT signaling pathway are associated with IBD …
including celiac disease and … to the JAK-STAT signaling pathway are associated with IBD …
Exploitable signaling pathways for the treatment of inflammatory bowel disease
… In a nutshell, it has been proven that an active JAK/STAT pathway functions in inflammatory
bowel disease by controlling numerous distinct T cell signaling activities [82, 83] (Fig. 4). …
bowel disease by controlling numerous distinct T cell signaling activities [82, 83] (Fig. 4). …
Novel signal transduction pathways: analysis of STAT‐3 and Rac‐1 signaling in inflammatory bowel disease
R Atreya, I Atreya, MF Neurath - … of the New York Academy of …, 2006 - Wiley Online Library
… bowel disease still remains unclear, considerable progress has been made in the identification
of novel signal transduction pathways … of signal transduction pathways that are elemental …
of novel signal transduction pathways … of signal transduction pathways that are elemental …
Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease
… Inflammatory bowel disease (IBD) is characterised by a … 7 The primary regulatory pathways
for many of the functional and … as a major cytokine signalling pathway has recently been …
for many of the functional and … as a major cytokine signalling pathway has recently been …
Integrating immunologic signaling networks: the JAK/STAT pathway in colitis and colitis-associated cancer
S Zundler, MF Neurath - Vaccines, 2016 - mdpi.com
… Cytokines are believed to be crucial mediators of chronic intestinal inflammation in inflammatory
bowel diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC). Many of …
bowel diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC). Many of …
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