JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

A Salas, C Hernandez-Rocha, M Duijvestein… - Nature reviews …, 2020 - nature.com
disease is driven by multiple immune pathways, it … –STAT signalling and the pathways
relevant to intestinal homeostasis and pathology that provide the rationale for JAK–STAT pathway

Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease

M Coskun, M Salem, J Pedersen, OH Nielsen - Pharmacological research, 2013 - Elsevier
… through the JAK/STAT pathway and regulate the … /STAT signaling pathways also have
been implicated in the pathogenesis of several diseases, including inflammatory bowel disease (…

Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease

L Wang, Y Hu, B Song, Y Xiong, J Wang, D Chen - Inflammation Research, 2021 - Springer
… Majority of cytokines exert their functions through the JAK/STAT pathway, and contribute to
the … operation and interaction of various intestinal cells in IBD through the JAK/STAT pathway. …

Signaling pathways associated with inflammatory bowel disease

J Wei, J Feng - Recent patents on inflammation & allergy drug …, 2010 - ingentaconnect.com
… (JAK/STAT pathway will be described below) Finally, antiapoptotic proteins and pro-… Role
of the JNK signal transduction pathway in inflammatory bowel disease. World J Gastroenterol …

Phytochemicals targeting JAK–STAT pathways in inflammatory bowel disease: Insights from animal models

SY Moon, KD Kim, J Yoo, JH Lee, C Hwangbo - Molecules, 2021 - mdpi.com
… This review describes the significance of the JAK–STAT pathway as a current therapeutic …
can ameliorate disease symptoms by affecting the JAK–STAT pathway in vivo in IBD disease

JAK-STAT pathway regulation of intestinal permeability: pathogenic roles and therapeutic opportunities in inflammatory bowel disease

H Lei, MS Crawford, DF McCole - Pharmaceuticals, 2021 - mdpi.com
… trigger disease activity in chronic inflammatory bowel disease (… other inflammatory diseases,
including celiac disease and … to the JAK-STAT signaling pathway are associated with IBD …

Exploitable signaling pathways for the treatment of inflammatory bowel disease

A Tiwari, A Jain, A Verma… - Current Signal …, 2017 - ingentaconnect.com
… In a nutshell, it has been proven that an active JAK/STAT pathway functions in inflammatory
bowel disease by controlling numerous distinct T cell signaling activities [82, 83] (Fig. 4). …

Novel signal transduction pathways: analysis of STAT‐3 and Rac‐1 signaling in inflammatory bowel disease

R Atreya, I Atreya, MF Neurath - … of the New York Academy of …, 2006 - Wiley Online Library
bowel disease still remains unclear, considerable progress has been made in the identification
of novel signal transduction pathways … of signal transduction pathways that are elemental …

Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease

S Schreiber, P Rosenstiel, J Hampe, S Nikolaus… - Gut, 2002 - gut.bmj.com
… Inflammatory bowel disease (IBD) is characterised by a … 7 The primary regulatory pathways
for many of the functional and … as a major cytokine signalling pathway has recently been …

Integrating immunologic signaling networks: the JAK/STAT pathway in colitis and colitis-associated cancer

S Zundler, MF Neurath - Vaccines, 2016 - mdpi.com
… Cytokines are believed to be crucial mediators of chronic intestinal inflammation in inflammatory
bowel diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC). Many of …