Interleukin-6 trans-signaling in inflammatory bowel disease

K Mitsuyama, M Sata, S Rose-John - Cytokine & growth factor reviews, 2006 - Elsevier
… Inflammatory bowel disease (IBD), in particular Crohn's disease and ulcerative … disease is
complex, involving a wide range of molecules including cytokines [1], [2], [3]. Interleukin-6 (IL-6

[HTML][HTML] Interleukin 6: biological significance and role in inflammatory bowel diseases

A Pawłowska-Kamieniak, P Krawiec… - … in Clinical and …, 2021 - advances.umw.edu.pl
Interleukin 6 and its role in transmission of the activation signal Interleukin 6 (IL-6) is a …
Interestingly, IL-6 can both boost and reduce inflammation. It is one of the pro-inflammatory …

Significance of interleukin-6 in patients with inflammatory bowel disease

K Mitsuyama, M Sata, K Tanikawa - Gastroenterologia Japonica, 1991 - Springer
interleukin-6 (IL-6) in patients with inflammatory bowel disease (IBD) was studied by measuring
the IL-6 … Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of unkonwn …

Interleukin6 and soluble interleukin6 receptor in the colonic mucosa of inflammatory bowel disease

T Hosokawa, K Kusugami, K Ina, T Ando… - Journal of …, 1999 - Wiley Online Library
6 and IL-6 receptor (IL-6R) may be important to the pathogenesis of inflammatory bowel
disease … Although the cause of inflammatory bowel disease (IBD) still remains controversial, …

Colonic mucosal interleukin-6 in inflammatory bowel disease

K Mitsuyama, E Sasaki, A Toyonaga, H Ikeda… - Digestion, 1991 - karger.com
… The levels of interleukin-6 decreased in parallel with clinical improvement following the start
of ther apy in patients with both forms of inflammatory bowel disease. Mucosal interleukin-6

Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6.

K Mitsuyama, A Toyonaga, E Sasaki, O Ishida, H Ikeda… - Gut, 1995 - gut.bmj.com
… Discussion This study showed that excess sIL-6R circulates in patients with active inflammatory
bowel disease. Simultaneous determination of IL-6 concentrations showed that it was …

Tumor necrosis factor-α, interleukin-1β, and interleukin-6 expression in inflammatory bowel disease

C Stevens, G Walz, C Singaram, ML Lipman… - Digestive diseases and …, 1992 - Springer
… not vary between inflammatory bowel disease and control … bowel disease inflammatory
specimens while IL-6 mRNA levels … of IL-6 protein in inflammatory bowel disease specimens by …

Is interleukin-6 important in inflammatory bowel disease?

K Koss, J Satsangi, KI Welsh, DP Jewell - Genes & Immunity, 2000 - nature.com
… to inflammatory bowel disease. The functional effects of interleukin-6 (IL-6) polymorphisms
in … flanking region of IL-6 gene were studied in 192 inflammatory bowel disease patients and …

Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance

J Mudter, MF Neurath - Inflammatory bowel diseases, 2007 - academic.oup.com
… (UC) are chronic inflammatory bowel diseases (IBDs) occurring … interleukin 6 production in
blood mononuclear leukocytes obtained from patients with active inflammatory bowel disease

Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease

S Rose-John, K Mitsuyama… - Current …, 2009 - ingentaconnect.com
… Abstract: The complex pathogenesis of inflammatory bowel disease (IBD) and inflammation
… Recent investigations underline the fundamental role of interleukin6 (IL-6) signaling in the …