Targeting TNF-α for the treatment of inflammatory bowel disease

T Billiet, P Rutgeerts, M Ferrante… - Expert opinion on …, 2014 - Taylor & Francis
… advent of tumor necrosis factor (TNF) antagonists represented a radical change in the
management of inflammatory bowel disease (IBD). Both in short- and long-term, anti-TNF therapy …

Development of inflammatory bowel disease during anti-TNF-α therapy for inflammatory rheumatic disease. A nationwide series

…, É Houvenagel, V Goëb, D Fouache, A Martin… - Joint Bone Spine, 2012 - Elsevier
… typical Crohn's disease in eight cases, Crohn's-like disease in … For all cases, each TNF-α
blocking agent was discontinued … Cases of inflammatory bowel disease appearing under TNFα

Systematic review: antibodies and anti‐TNFα levels in inflammatory bowel disease

M Chaparro, I Guerra… - Alimentary …, 2012 - Wiley Online Library
… of antibodies against anti-TNF-α drugs and the relationship … TNF-α antibodies and
measuring drug serum levels to optimise treatment of patients with inflammatory bowel disease

… relevance of soluble TNF-α, transmembrane TNF-α and TNF-signal transduction in gastrointestinal diseases with special reference to inflammatory bowel diseases

MH Holtmann, M Schütz, PR Galle… - Zeitschrift für …, 2002 - thieme-connect.com
TNF-α Tumor necrosis factor α (TNF-α) belongs to a family of structurally related ligands that
… Almost all members of the TNF familiy exert their effects as transmembrane proteins through …

[HTML][HTML] Inflammatory bowel disease: How effective is TNF-α suppression?

WC Lo, V Arsenescu, RI Arsenescu, A Friedman - PloS one, 2016 - journals.plos.org
… Currently, anti-TNF antibodies represent the main group of biologic … TNF-α blockade in our
mathematical model. For modeling the TNF-α blockade, we fix the concentration of TNF-α (I α

Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease

EJ Breese, CA Michie, SW Nicholls, SH Murch… - Gastroenterology, 1994 - Elsevier
… inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor a
(TNF-… of TNF-a secreting cells isolated from mucosal biopsy specimens of children with Crohn’s …

TNF-alpha blockers in inflammatory bowel diseases: practical recommendations and a user's guide: an update

M Vulliemoz, S Brand, P Juillerat, C Mottet… - Digestion, 2020 - karger.com
… (anti-TNF) antagonists have been the mainstay in the treatment of inflammatory bowel
diseases (… Summary: This review article aimed to provide an update on recent advances in TNF

Role of cytokines in the pathogenesis of inflammatory bowel disease

KA Papadakis, SR Targan - Annual review of medicine, 2000 - annualreviews.org
bowel disease (IBD)have paralleled our understanding of the pathophysiology of ulcerative
colitisand Crohn’s disease. … of ulcerative colitis andCrohn’s disease have been elucidated. …

Meta‐analysis: peri‐operative anti‐TNF α treatment and post‐operative complications in patients with inflammatory bowel disease

N Narula, D Charleton… - Alimentary pharmacology & …, 2013 - Wiley Online Library
… to assess the impact of peri-operative use of TNFα antagonists on post-operative complications
such as infection and wound healing in patients with inflammatory bowel disease (IBD). …

[HTML][HTML] local tumor necrosis factor-α inhibition in inflammatory bowel disease

B Gareb, AT Otten, HW Frijlink, G Dijkstra… - Pharmaceutics, 2020 - mdpi.com
… (Crohn’s disease OR inflammatory bowel disease OR ulcerative … (tumor necrosis factor OR
tumor necrosis factor-alpha OR TNF) AND (Crohn’s disease OR inflammatory bowel disease